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THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
The method can be applied to most laboratory animals in the conscious state and is based on the use of 2‐deoxy‐D‐[14C]glucose as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues.
TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC RATE IN HUMANS WITH (F‐18)2‐FLUORO-2‐DEOXY-D‐GLUCOSE: VALIDATION OF METHOD
- M. Phelps, S. C. Huang, E. Hoffman, C. Selin, L. Sokoloff, D. Kuhl
- BiologyAnnals of neurology
- 1 December 1980
The data indicate that cerebral FDG-6-PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method
The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
Measurement of local cerebral blood flow with iodo [14C] antipyrine.
- O. Sakurada, C. Kennedy, J. Jehle, J. Brown, G. L. Carbin, L. Sokoloff
- BiologyThe American journal of physiology
Iodo[14C]antipyrine appears, therefore, to be a satisfactory nonvolatile tracer for the measurement of local cerebral blood flow.
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
- Y. Itoh, T. Esaki, L. Sokoloff
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 31 March 2003
In vitro dichloroacetate stimulated glucose and lactate oxidation to CO2 and reduced lactate release mainly in astroglia, indicating that limitations in glucose and lactate oxidation byAstroglia may be due to a greater balance of PDH toward the inactive form and the compartmentalization may be neither complete nor entirely obligatory.
The [18F]Fluorodeoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization in Mane
A mathematical model and derived operational equation are used which enable local cerebral glucose consumption to be calculated in terms of the following measurable variables: gray matter, white matter, and whole brain metabolic rates, calculated as a weighted average based on the approximate volume of each structure.
RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
- L. Sokoloff
- BiologyJournal of neurochemistry
- 1 July 1977
The recently developed [14C]deoxyglucose technique (SOKOLOFF et al., 1977) appears to fulfill the need to measure quantitatively the local rates of glucose utilization simultaneously in all the macroscopically visible structures of the brain.
Local Cerebral Blood Flow during Hibernation, a Model of Natural Tolerance to “Cerebral Ischemia”
- K. Frerichs, C. Kennedy, L. Sokoloff, J. Hallenbeck
- MedicineJournal of cerebral blood flow and metabolism…
- 1 March 1994
Hibernation appears to be actively regulated, and hormonal factors may be involved, and the identification and characterization of such factors and of the mechanisms used by hibernating species to increase ischemic tolerance and to blunt the destructive effects of ischemia may enable to prevent or minimize the loss of homeostatic control during and after cerebral ischemIA in other species.
Activity‐dependent Energy Metabolism in Rat Posterior Pituitary Primarily Reflects Sodium Pump Activity
This report provides evidence that the increase in glucose utilization evoked by functional activation in neural tissue is due to the opening of Na+ channels and activation of Na+, K+ -ATPase activity.