Alarmins

Known as: DAMP, Damage-Associated Molecular Pattern Molecule, Danger Associated Molecular Pattern 
A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from… (More)
National Institutes of Health

Papers overview

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Review
2016
Review
2016
High Mobility Group Box 1 protein was discovered as a nuclear protein, but it has a "second life" outside the cell where it acts… (More)
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Highly Cited
2014
Highly Cited
2014
FOXP3+ regulatory T cells (Treg cells) are abundant in the intestine, where they prevent dysregulated inflammatory responses to… (More)
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Review
2012
Review
2012
HMGB1 is a non-histone nuclear protein that can serve as an alarmin to drive the pathogenesis of inflammatory and autoimmune… (More)
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Highly Cited
2012
Highly Cited
2012
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous… (More)
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Review
2009
Review
2009
Neutrophils are the first major population of leukocyte to infiltrate infected or injured tissues and are crucial for initiating… (More)
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Highly Cited
2009
Highly Cited
2009
The immune system responds to pathogens by a variety of pattern recognition molecules such as the Toll-like receptors (TLRs… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Interleukin-33 (IL-33) is an IL-1-like cytokine ligand for the IL-1 receptor-related protein ST2, that activates mast… (More)
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Review
2007
Review
2007
Multicellular animals detect pathogens via a set of receptors that recognize pathogen-associated molecular patterns (PAMPs… (More)
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Review
2007
Review
2007
In response to infection and/or tissue injury, cells of the host innate immune system rapidly produce a variety of structurally… (More)
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Review
2005
Review
2005
The recruitment and activation of antigen-presenting cells are critical early steps in mounting an immune response. Many… (More)
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