Akinesia

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders, affecting… Expand

Parkinson’s disease (PD) is a neurodegenerative disorder caused by insufficient dopamine production due to the loss of 50% to 70… Expand

BACKGROUND Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced… Expand

In an attempt to define clinically relevant models of akinesia and dyskinesia in 6‐hydroxydopamine (6‐OHDA)‐lesioned rats, we… Expand

Using functional MRI (fMRI), we have studied the changes induced by the performance of a complex sequential motor task in the… Expand

BACKGROUND In many patients with idiopathic Parkinson's disease, treatment with levodopa is complicated by fluctuations between… Expand

Methods for the assessment of akinesia in the unilateral rat Parkinson model have so far been lacking. The experiments reported… Expand

Using positron emission tomography (PET) we previously showed that activation of the putamen, supplementary motor area, and… Expand

Although it is known that Parkinson's disease results from a loss of dopaminergic neurons in the substantia nigra, the resulting… Expand

A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in… Expand