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Aflatoxin B1

Known as: Aflatoxin B1 [Chemical/Ingredient], (6AR-cis)-2,3,6a,9a-tetrahydro-4-methoxycyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, AFB1 
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (2)

Aflatoxin BPoisons
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (6)

aflatoxin B1-2,3-oxideaflatoxin B1-8,9-dichlorideaflatoxin B1-8,9-dihydrodiol-Tris buffer complexaflatoxin B1-DNA adduct

Papers overview

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Highly Cited
1984
Highly Cited
1984
An investigation of HPLC post-column iodination conditions for the enhancement of aflatoxin B1 fluorescence.
A systematic investigation was carried out of the conditions employed for the post-column iodination reaction used to enhance… 
Highly Cited
1984
Highly Cited
1984
Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro.
Forty-two compounds belonging to various chemical groups have been tested for their ability to suppress formation of aflatoxin B1… 
Highly Cited
1983
Highly Cited
1983
Some mass-spectral and n.m.r. analytical studies of a glutathione conjugate of aflatoxin B1.
A system for the formation of an aflatoxin B1-reduced glutathione conjugate in vitro was developed, capable of yielding 80… 
1982
1982
Sensitivity of aflatoxin b1 to ionizing radiation
Aflatoxin B1 in a 5-micrograms/ml water solution was sensitive to ionizing radiation. Inactivation was assayed by the Ames… 
Highly Cited
1980
Highly Cited
1980
Metabolism and activation of aflatoxin B1 by reconstituted cytochrome P-450 system of rat liver.
Metabolism and activation of aflatoxin B1, a potent hepatocarcinogenic and mutagenic mycotoxin of Aspergillus flavus, were… 
Highly Cited
1979
Highly Cited
1979
Effects of dietary fat on hepatic mixed-function oxidases and hepatocellular carcinoma induced by aflatoxin B1 in rats.
Some groups of male Sprague-Dawley rats were fed a diet containing either 28% beef fat and 2% corn oil or 30% corn oil (high fat… 
Highly Cited
1978
Highly Cited
1978
Reduced nicotinamide adenine dinucleotide phosphate-dependent formation of 2,3-dihydro-2,3-dihydroxyaflatoxin B1 from aflatoxin B1 by hepatic microsomes.
2,3-Dihydro-2,3-dihydroxyaflatoxin B1 (dihydrodiol) was formed as a major metabolite in the incubation of aflatoxin B1 with rat… 
Highly Cited
1977
Highly Cited
1977
Mechanism of aflatoxin B1 inhibition of rat hepatic nuclear RNA synthesis.
This paper reports the evidence for the existence of multiple sites of action of aflatoxin B1 in relation to its inhibition of… 
Highly Cited
1975
Highly Cited
1975
The reactivity and carcinogenicity of aflatoxin B1-2,3-dichloride, a model for the putative 2,3-oxide metabolite of aflatoxin B1.
Aflatoxin B1-2,3-dichloride (AFB1-Cl2) was synthesized as a model for the probable ultimate carcinogen, aflatoxin B1-2,3-oxide… 
Highly Cited
1966
Highly Cited
1966
Experimental Detoxification of Groundnut Meals containing Aflatoxin
DURING work involving sterilization by autoclaving of groundnut meals containing aflatoxin, the hepatotoxic metabolites of… 
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