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Aflatoxin B1

Known as: Aflatoxin B1 [Chemical/Ingredient], (6AR-cis)-2,3,6a,9a-tetrahydro-4-methoxycyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, AFB1 
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (2)

Aflatoxin BPoisons
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (6)

aflatoxin B1-2,3-oxideaflatoxin B1-8,9-dichlorideaflatoxin B1-8,9-dihydrodiol-Tris buffer complexaflatoxin B1-DNA adduct

Papers overview

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Highly Cited
1984
Highly Cited
1984
An investigation of HPLC post-column iodination conditions for the enhancement of aflatoxin B1 fluorescence.
A systematic investigation was carried out of the conditions employed for the post-column iodination reaction used to enhance… 
Highly Cited
1983
Highly Cited
1983
Some mass-spectral and n.m.r. analytical studies of a glutathione conjugate of aflatoxin B1.
A system for the formation of an aflatoxin B1-reduced glutathione conjugate in vitro was developed, capable of yielding 80… 
1982
1982
Sensitivity of aflatoxin b1 to ionizing radiation
Aflatoxin B1 in a 5-micrograms/ml water solution was sensitive to ionizing radiation. Inactivation was assayed by the Ames… 
Highly Cited
1979
Highly Cited
1979
Effects of dietary fat on hepatic mixed-function oxidases and hepatocellular carcinoma induced by aflatoxin B1 in rats.
Some groups of male Sprague-Dawley rats were fed a diet containing either 28% beef fat and 2% corn oil or 30% corn oil (high fat… 
1979
1979
Aflatoxin B1 mutagenesis, DNA binding, and adduct formation in Salmonella typhimurium.
Salmonella typhimurium strain TM677 was mutagenized with aflatoxin B1 (AFB1) in liquid suspension culture in the presence of a… 
Highly Cited
1978
Highly Cited
1978
Aflatoxin B1 induction of hepatocellular carcinoma in the embryos of rainbow trout (Salmo gairdneri).
Liver cancer in rainbow trout was induced by exposure of fertile eggs to an aqueous, 0.5 ppm (microgram/ml) solution of aflatoxin… 
Highly Cited
1978
Highly Cited
1978
Reduced nicotinamide adenine dinucleotide phosphate-dependent formation of 2,3-dihydro-2,3-dihydroxyaflatoxin B1 from aflatoxin B1 by hepatic microsomes.
2,3-Dihydro-2,3-dihydroxyaflatoxin B1 (dihydrodiol) was formed as a major metabolite in the incubation of aflatoxin B1 with rat… 
Highly Cited
1977
Highly Cited
1977
Mechanism of aflatoxin B1 inhibition of rat hepatic nuclear RNA synthesis.
This paper reports the evidence for the existence of multiple sites of action of aflatoxin B1 in relation to its inhibition of… 
1976
1976
Enzymatic conversion of sterigmatocystin into aflatoxin B1 by cell-free extracts of Aspergillus parasiticus
A cell-free extract, prepared from Aspergillus parasiticus ATCC 15517 grown in synthetic medium, was active in converting [14C… 
1967
1967
The effects of aflatoxin B1 and dimethylsulfoxide on thymidine-3H uptake and mitosis in rat liver.
DNA synthesis, measured by thymidine-3H labeling of nuclei in autoradiographs, and mitosis have been studied in the livers of 148…