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Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro.
Forty-two compounds belonging to various chemical groups have been tested for their ability to suppress formation of aflatoxin B1--DNA adduct mediated by microsome in vitro. While many of theseExpand
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Modulation by plant flavonoids and related phenolics of microsome catalyzed adduct formation between benzo[a]pyrene and DNA.
Twenty-six flavonoids and related compounds were screened for their ability to modulate microsome mediated covalent adduct formation between [3H]benzo[a]pyrene ([3H]BP) and DNA in vitro. Some ofExpand
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Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1.
Curcumin, in a dose-dependent manner, inhibited the formation of covalent adduct between aflatoxin B1 and DNA, as catalyzed by microsomes or a reconstituted microsomal monooxygenase system. ItsExpand
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Modulation of aflatoxin B1 activated protein kinase C by phenolic compounds.
Several natural phenolic compounds were tested in vitro for their effect on the activity of protein kinase C isolated from liver cytosol, particulate and nuclear fractions of normal and aflatoxin B1Expand
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Signal transduction mechanism in response to aflatoxin B1 exposure: protein kinase C activity.
A single dose of the carcinogen aflatoxin B1 (7 mg/kg body weight) to male Wistar rats significantly enhanced the hepatic activity of protein kinase C in the particulate and nuclear fractions. TheExpand
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Inhibition of microsomal activation of aflatoxin B1 by 3-dehydroretinol and 3-dehydroretinyl palmitate.
Two vitamin A2 compounds (3-dehydroretinol and 3-dehydroretinyl palmitate) which are predominantly present in fresh water fish have been found to be very effective in inhibiting the microsomeExpand
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Alteration of energy-linked functions in rat hepatic mitochondria following aflatoxin B1 administration.
Respiratory activity in hepatic mitochondria have been examined following administration of the carcinogen aflatoxin, (AFB1) to rats. Measurement in isolated mitochondria of respiration rates inExpand
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Properties of DNA treated with S-(1,2-dichlorovinyl)-L-cysteine and a lyase.
Abstract When 35 S-(1,2-dichlorovinyl)- l -cysteine (DCVC) was cleaved in vitro by a lyase from bovine kidney in the presence of DNA, there occurred a rapid uptake of radioactivity, firmly bound byExpand
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Enzymes from bovine and turkey kidneys which cleave S-(1,2-dichlorovinyl)-L-cysteine.
Abstract 1. 1. Bovine and turkey kidneys were used to prepare concentrates of a lyase which can cleave S-(1,2-dichlorovinyl)- l -cysteine. 2. 2. Both enzymes had similar properties, producingExpand
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Effect of plant flavonoids on microsome catalyzed reactions of aflatoxin B1 leading to activation and DNA adduct formation.
Twenty-six plant phenolic flavonoids were tested for their ability to modulate microsome mediated activation of aflatoxin B1 (AFB1) and covalent adduct formation of activated metabolites with DNA.Expand
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