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Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data… Expand The recent insight that brown adipocytes and muscle cells share a common origin and in this respect are distinct from white… Expand Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem… Expand The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing… Expand Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast, the SIR2 gene mediates the life… Expand The adipocyte plays a critical role in energy balance. Adipose tissue growth involves an increase in adipocyte size and the… Expand Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a… Expand We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively… Expand Prostaglandins (PGs) of the J2 series form in vivo and exert effects on a variety of biological processes. While most of PGs… Expand Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An… Expand