Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Adenosine Deaminase Inhibitors

Known as: ADA Inhibitors, ADA Inhibitor, Inhibitors, Adenosine Deaminase 
Any substance that inhibits adenosine deaminase, an enzyme involved with the degradation of adenine in purine metabolism and that acts as a positive… Expand
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (4)

5-(formylamino)imidazole ribosidePentostatinadechlorinadecypenol
Adenosine Deaminase Inhibitors [MoA]In Bloodaspects of radiation effectschemical synthesis
Expand

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A(1) adenosine receptors.
Extracellular adenosine-induced apoptosis of CW2 human colonic cancer cells by activating caspase-3, -8 and -9, and the effect… Expand
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Inhibition of Adenosine Deaminase Attenuates Inflammation in Experimental Colitis
Adenosine modulates the immune system and inhibits inflammation via reduction of cytokine biosynthesis and neutrophil functions… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 5
Is this relevant?
Review
1999
Review
1999
The SCL gene: from case report to critical hematopoietic regulator.
T HIS STORY BEGINS with a seminal case report describing a 16-year-old boy who presented with acute lymphoblastic leukemia (ALL… Expand
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat
&NA; The present study examined the spinal antinociceptive effects of adenosine analogs and inhibitors of adenosine kinase and… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.
The purine nucleoside adenosine (9-beta-D-ribofuranosyladenine) inhibits a number of lymphocyte functions in vitro, including the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Brain Adenosine and Transmitter Amino Acid Release from the Ischemic Rat Cerebral Cortex: Effects of the Adenosine Deaminase Inhibitor Deoxycoformycin
Abstract: The effects of a potent adenosine deaminase inhibitor, deoxycoformycin, on purine and amino acid neuro‐transmitter… Expand
Is this relevant?
Highly Cited
1984
Highly Cited
1984
Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.
Selective failure of lymphoid development occurs in genetic deficiency of adenosine deaminase (ADA). We examined the in vivo… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1982
Highly Cited
1982
Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre
A thin dialysis tube was implanted stereotaxically under halothane anesthesia in the caudate nucleus of Sprague-Dawley rats and… Expand
Is this relevant?
Highly Cited
1977
Highly Cited
1977
Specificity of adenosine deaminase inhibitors.
Abstract The specificity of the potent adenosine deaminase inhibitors deoxycoformycin (covidarabine), coformycin and erythro -9… Expand
Is this relevant?
Highly Cited
1976
Highly Cited
1976
Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis.
The biochemical mechanisms by which a genetically determined deficiency of adenosine deaminase leads to immunodeficiency are… Expand
  • figure 1
  • figure 2
  • table I
  • figure 3
  • table I
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE