Adenosine Deaminase Inhibitors

Known as: ADA Inhibitors, ADA Inhibitor, Inhibitors, Adenosine Deaminase 
Any substance that inhibits adenosine deaminase, an enzyme involved with the degradation of adenine in purine metabolism and that acts as a positive… (More)
National Institutes of Health

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5-(formylamino)imidazole ribosidePentostatinadechlorinadecypenol
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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2007
2007
Inhibition of adenosine deaminase attenuates inflammation in experimental colitis.
Adenosine modulates the immune system and inhibits inflammation via reduction of cytokine biosynthesis and neutrophil functions… (More)
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2006
2006
Binding free energy calculations of adenosine deaminase inhibitors.
The interactions between four inhibitors and adenosine deaminase (ADA) were examined by calculating their binding free energies… (More)
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2006
2006
Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938.
Adenosine has anti-inflammatory activity. Adenosine deaminase (EC 3.5.4.4) metabolizes extracellular adenosine, resulting in an… (More)
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1998
1998
Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat
The present study examined the spinal antinociceptive effects of adenosine analogs and inhibitors of adenosine kinase and… (More)
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1998
1998
Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: role of A2B receptors.
The objective of this study was to characterize the effects of exogenous and endogenous (cardiac fibroblast-derived) adenosine on… (More)
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Highly Cited
1997
Highly Cited
1997
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.
The purine nucleoside adenosine (9-beta-D-ribofuranosyladenine) inhibits a number of lymphocyte functions in vitro, including the… (More)
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1997
1997
Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors.
The physiological role of adenosine (Ado) is well known. Although a number of pharmacological attempts have been made to… (More)
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1997
1997
An adenosine deaminase inhibitor prevents puromycin aminonucleoside nephrotoxicity.
Puromycin aminonucleoside (PAN) toxicity was totally inhibited in the rat in vivo and in cultured glomerular epithelial cells… (More)
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Highly Cited
1997
Highly Cited
1997
Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors.
BACKGROUND Because proliferation of cardiac fibroblasts participates in cardiac hypertrophy/remodeling associated with… (More)
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1996
1996
Adenosine kinase inhibitors augment release of adenosine from spinal cord slices.
Inhibitors of adenosine kinase, but not adenosine deaminase, produce antinociception when administered spinally. In this study… (More)
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