Adenosine Deaminase Inhibitors [MoA]

Known as: Adenosine Deaminase Inhibitors 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
012319772017

Papers overview

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2009
2009
A number of pyrazolo[3,4-d]pyrimidin-4-ones bearing either alkyl or arylalkyl substituents in position 2 of the nucleus were… (More)
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2005
2005
There is an urgent need to discontinue the use of highly toxic compounds still in use for treatment of the encephalitic stage of… (More)
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2005
2005
This study reports the synthesis of a number of 1- and 2-alkyl derivatives of the 4-aminopyrazolo[3,4-d]pyrimidine (APP) nucleus… (More)
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2004
2004
We disclose herein optimization efforts around the novel, highly potent non-nucleoside adenosine deaminase (ADA) inhibitor, 1-[(R… (More)
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2000
2000
BACKGROUND Low flow or no flow is a prefinal step after reperfusion of hepatic allografts. Adenosine is an intrinsic key… (More)
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1998
1998
The antifungal activity of the nucleoside analog 3'-deoxyadenosine (cordycepin) was studied in a murine model of invasive… (More)
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1993
1993
We investigated the effect of the adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and coformycin on… (More)
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1985
1985
Cerebral blood flow in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for… (More)
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1983
1983
The concept of limiting irreversible damage due to ischemic arrest by inhibiting nucleoside breakdown was tested in the isolated… (More)
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