Adenosine Deaminase Inhibitors [MoA]

A number of pyrazolo[3,4-d]pyrimidin-4-ones bearing either alkyl or arylalkyl substituents in position 2 of the nucleus were… (More)

There is an urgent need to discontinue the use of highly toxic compounds still in use for treatment of the encephalitic stage of… (More)

This study reports the synthesis of a number of 1- and 2-alkyl derivatives of the 4-aminopyrazolo[3,4-d]pyrimidine (APP) nucleus… (More)

We disclose herein optimization efforts around the novel, highly potent non-nucleoside adenosine deaminase (ADA) inhibitor, 1-[(R… (More)

BACKGROUND Low flow or no flow is a prefinal step after reperfusion of hepatic allografts. Adenosine is an intrinsic key… (More)

The antifungal activity of the nucleoside analog 3'-deoxyadenosine (cordycepin) was studied in a murine model of invasive… (More)

We investigated the effect of the adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and coformycin on… (More)

Cerebral blood flow in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for… (More)

The concept of limiting irreversible damage due to ischemic arrest by inhibiting nucleoside breakdown was tested in the isolated… (More)