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Activation, Metabolic

Known as: Metabolic Activation, activation metabolic, metabolic induction 
The conversion of an exogenous substance by a biological system resulting in the production on an active metabolite.
National Institutes of Health

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2 relations
aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2006
Highly Cited
2006
High-specificity and high-sensitivity genotoxicity assessment in a human cell line: validation of the GreenScreen HC GADD45a-GFP genotoxicity assay.
Review
2005
Review
2005
The role of metabolic activation in drug-induced hepatotoxicity.
The importance of reactive metabolites in the pathogenesis of drug-induced toxicity has been a focus of research interest since… 
Highly Cited
2005
Highly Cited
2005
Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.
Highly Cited
2003
Highly Cited
2003
Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study.
Highly Cited
2003
Highly Cited
2003
Screening of medicinal plants used in South African traditional medicine for genotoxic effects.
Highly Cited
2000
Highly Cited
2000
Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1…
The human CYP2A subfamily comprises three genes, CYP2A6, CYP2A7, and CYP2A13. CYP2A6 is active toward many carcinogens and is the… 
Highly Cited
1999
Highly Cited
1999
Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA
Highly Cited
1994
Highly Cited
1994
The Antiaggregating Activity of Clopidogrel Is due to a Metabolic Activation by the Hepatic Cytochrome P450-1A
Summary Clopidogrel and ticlopidine are two well known selective anti-ADP agents which are inactive in vitro and must be… 
Highly Cited
1992
Highly Cited
1992
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.
An acetyltransferase-overexpressing strain of Salmonella typhimurium (NM2009) has been used to investigate roles of human liver… 
Review
1988
Review
1988
A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures.
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