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Primary mutagenicity screening of food additives currently used in Japan.
Report from the In Vitro Micronucleus Assay Working Group
At the Washington International Workshop on Genotoxicity Test Procedures (March 25–26, 1999), the current methodologies and data for the in vitro micronucleus test were reviewed. From this,…
Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA.
- S. R. Kim, G. Maenhaut-Michel, H. Ohmori
- BiologyProceedings of the National Academy of Sciences…
- 9 December 1997
The results establish that E. coli has at least two distinct pathways for SOS-induced mutagenesis: one dependent on umuDC and the other on dinB/P, which is identical to dinB, an SOS gene previously localized near the lac locus.
Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU).
It is concluded that the in vitro micronucleus test could be used in place of the chromosomal aberration test as a simple and rapid method for detecting clastogens and aneugens in vitro.
Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possessing elevated levels of both nitroreductase and acetyltransferase activity.
Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals.
Development of genotoxicity assay systems that use aquatic organisms.
An application of Acridine Orange fluorescent staining to the micronucleus test.
A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures.