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Actin, Cytoplasmic 1

Known as: ACTB, Beta-Actin, PS1TP5-Binding Protein 1 
Actin, cytoplasmic 1 (375 aa, ~42 kDa) is encoded by the human ACTB gene. This protein is involved in both cell motility and morphology.
National Institutes of Health

Related topics

Related topics

14 relations
ACTB geneCell MovementCytokinesisCytoskeletal Gene

Papers overview

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Highly Cited
2006
Highly Cited
2006
An essential role for β-actin mRNA localization and translation in Ca2+-dependent growth cone guidance
Axon pathfinding requires directional responses of growth cones to extracellular cues, which have been shown to involve local… 
Highly Cited
2003
Highly Cited
2003
Smn, the spinal muscular atrophy–determining gene product, modulates axon growth and localization of β-actin mRNA in growth cones of motoneurons
Spinal muscular atrophy (SMA), a common autosomal recessive form of motoneuron disease in infants and young adults, is caused by… 
Highly Cited
2003
Highly Cited
2003
Activity-Dependent Trafficking and Dynamic Localization of Zipcode Binding Protein 1 and β-Actin mRNA in Dendrites and Spines of Hippocampal Neurons
RNA binding proteins may be important mediators of the activity-dependent transport of mRNAs to dendritic spines of activated… 
Highly Cited
1999
Highly Cited
1999
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
The molecular basis of aberrant hypermethylation of CpG islands observed in a subset of human colorectal tumors is unknown. One… 
Highly Cited
1997
Highly Cited
1997
Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.
PURPOSE Response rates to fluorouracil (5-FU)-based therapy remain low. As new, active agents are being tested, information… 
Highly Cited
1996
Highly Cited
1996
Single-copy transgenic mice with chosen-site integration.
We describe a general way of introducing transgenes into the mouse germ line for comparing different sequences without the… 
Highly Cited
1994
Highly Cited
1994
Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids.
Using a combination of in vivo and in vitro studies, we have investigated the impact of polyunsaturated fatty acids (PUFA) on the… 
Highly Cited
1992
Highly Cited
1992
ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients.
BACKGROUND ERCC1 and ERCC2 are human DNA repair genes that are associated with in vitro resistance to selected DNA-damaging… 
Highly Cited
1991
Highly Cited
1991
Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies.
Balloon catheter denudation of rat carotid artery that results in significant medial damage is followed by marked intimal smooth… 
Highly Cited
1984
Highly Cited
1984
Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.
We report the complete nucleotide sequence of a human beta actin cDNA. Both the 5' and 3' untranslated regions of the sequence… 
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