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Acronine

Known as: Acronine [Chemical/Ingredient], Acronycin, 7H-Pyrano(2,3-c)acridin-7-one, 3,12-dihydro-6-methoxy-3,3,12-trimethyl- 
A natural alkaloid with an acridine structure isolated from the bark of the plant Acronychia baueri (Australian scrub ash) with antineoplastic… 
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (8)

1,2-diacetoxy-1,2-dihydroacronycine1,2-dihydroxy-1,2-dihydroacronycine11-amino-6-demethoxyacronycine11-aminoacronycine

Broader (1)

Antineoplastic Agents, Phytogenic
In BloodProcess of secretionagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Protein recognition of the S23906-1-DNA adduct by nuclear proteins: direct involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
In a view to develop new DNA alkylating antitumour drugs, evaluating the precise mechanism of action and the molecular/cellular… 
Review
2002
Review
2002
Acronycine derivatives as promising antitumor agents.
Originally isolated from an Australian plant, acronycine is an antitumor alkaloid with poor water solubility and low potency. The… 
Highly Cited
2001
Highly Cited
2001
Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors.
S 23906-1 is a novel acronycine derivative selected on the basis of its potency in vitro. We investigated the antitumor activity… 
1989
1989
Elimination of chemoresistant multiple myeloma clonogenic colony-forming cells by combined treatment with a plasma cell-reactive monoclonal antibody and a P-glycoprotein-reactive monoclonal antibody.
Patients with multiple myeloma (MM) commonly become refractory to chemotherapy despite a favorable response to induction… 
1988
1988
Acronycine Epoxide: A New Acridone Alkaloid from Several Sarcomelicope Species
(1) Koller, G., Russ, H. (1937) Monatsh. Chem. 70,54. (2) Santesson, J. (1969) Acta Chem. Scand, 23, 3270. (3) Dutton, M. F… 
1984
1984
Chemistry of acronycine IV. Minor constituents of acronine and the phytochemistry of the genus Acronychia.
In the course of isolating acronycine (1) from an alkaloid fraction of the bark of Acronychia baueri (Rutaceae), five alkaloids… 
Highly Cited
1978
Highly Cited
1978
Uridine transport in novikoff rat hepatoma cells and other cell lines and its relationship to uridine phosphorylation and phosphorolysis
Time courses of [3H]uridine uptake as a function of uridine concentration were determined at 25° in untreated and ATP‐depleted… 
1974
1974
Microbial hydroxylation of acronycine.
1973
1973
Effects of the antineoplastic alkaloid acronycine on nucleoside uptake and incorporation into nucleic acids by cultured L5178Y cells.
The antineoplastic alkaloid acronycine inhibits the incorporation of extracellular nucleosides into the RNA and DNA of cultured… 
Highly Cited
1969
Highly Cited
1969
A synthesis of acronycine.
Improved syntheses of certain O-and N-methyl derivatives of 1,3-dihydroxy-acridone are described. Thermal rearrangement of the… 
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