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Phenolic Constituents of Selaginella doederleinii.
Lignans are described here for the first time in the family Selaginellaceae for their cytotoxic activity against L 929 murine cells accounts for the use of the plant in traditional Chinese medicine as an anticancer agent.
Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture,Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied.
In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum
In vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated and a pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and2-nitro substituents in the acrid one nucleus improved the antimalarial activities of the compounds.
Isolation and antibacterial activity of phenylpropanoid derivatives from Ballota nigra.
Five major compounds isolated from generative aerial parts of Ballota nigra exhibited a moderate antimicrobial activity against Proteus mirabilis and Staphylococcus aureus including one methicillin-resistant strain.
New dithiolopyrrolone antibiotics from Saccharothrix sp. SA 233. I. Taxonomy, fermentation, isolation and biological activities.
Three new natural antibacterial and antifungal dithiolopyrrolone antibiotics were isolated along with the known iso-butyropyrrothine and thiolutine from the fermentation broth of an actinomycete
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
None of the tested compounds affected the proliferation of skin fibroblasts 142BR suggesting a selective action against cancer cells, and buddlejasaponin IV and songarosaponin D exerted significant inhibition of NO production in LPS induced RAW 264.
alpha-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae).
The CH(2)Cl(2)/CH(3)OH (1/1) extract of the dried stem bark of Terminalia superba afforded two compounds, (7S,8R,7'R,8'S)-4'-hydroxy-4-methoxy-7,7'-epoxylignan and meso-(rel
Two new peltogynoids from Acacia nilotica Delile with kinase inhibitory activity.
Two new peltogynoids were isolated from the stem bark of Acacia nilotica (L.) Delile, together with the known triterpene lupenone, and the structures of the new compounds were established on the basis of their spectral data, mainly UV, NMR, and mass spectrometry.
Phenylpropanoids from Ballota nigra L. inhibit in vitro LDL peroxidation
The goal of this study was to test whether the major polyphenolic compounds extracted from Ballota nigra, four phenylpropanoid glycosides, verbascoside, forsythoside B, arenarioside, and ballotetroside and one non‐glycosidic phenyl Propanoid, caffeoyl‐L‐malic acid, inhibit Cu2+‐induced LDL peroxidation.
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.
A series of chalcones and pyrazoles was prepared to investigate their potential activity as Angiotensin I-Converting Enzyme (ACE) inhibitors and, among tested compounds, chalcone 7 exerted the highest activity.