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ASIC2 protein, human

Known as: Degenerin, BNaC1, Amiloride-Sensitive Brain Sodium Channel 
Acid-sensing ion channel 2 (512 aa, ~58 kDa) is encoded by the human ASIC2 gene. This protein is involved in both synaptic transmission and cation… 
National Institutes of Health

Related topics

Related topics

18 relations
ASIC2 geneCellular MembraneDegenerin Sodium ChannelsIntegral Membrane Proteins

Broader (1)

Acid Sensing Ion Channels

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Hyperactivation of the Mammalian Degenerin MDEG Promotes Caspase-8 Activation and Apoptosis*♦
Background: Hyperactivation of DEG/ENaC channels leads to cell death; however, the underlying mechanism for the cytotoxicity… 
2009
2009
ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry.
Acid-sensing ion channels (ASIC) are voltage-insensitive, cationic channels that have recently been identified in vascular smooth… 
Highly Cited
2008
Highly Cited
2008
Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach–brainstem axis
2008
2008
Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity
Ion channel hyperactivation can result in neuronal loss in injury, stroke and neurodegenerative disease. Acidosis-associated… 
2005
2005
The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability
Highly Cited
2004
Highly Cited
2004
Acid-Sensing Ion Channel 2 Contributes a Major Component to Acid-Evoked Excitatory Responses in Spiral Ganglion Neurons and Plays a Role in Noise Susceptibility of Mice
Ion channels in the degenerin-epithelial sodium channel (DEG-ENaC) family perform diverse functions, including mechanosensation… 
Review
2001
Review
2001
Acid detection by taste receptor cells.
Highly Cited
2001
Highly Cited
2001
Characterization of the Drosophila melanogaster alkali-metal/proton exchanger (NHE) gene family.
The NHE family of Na+/H+ exchangers is believed to play an essential role in animals, but may play an additional, specialised… 
2001
2001
Single-Channel Properties of Recombinant Acid-Sensitive Ion Channels Formed by the Subunits Asic2 and Asic3 from Dorsal Root Ganglion Neurons Expressed in Xenopus Oocytes
The acid-sensitive ion channels known as ASIC are gated by external protons. A set of these channels is expressed in dorsal root… 
1998
1998
Structural organisation of the gene encoding the α-subunit of the human amiloride-sensitive epithelial sodium channel
Abstract The human amiloride-sensitive epithelial sodium channel (ENaC) is a member of the degenerin/ENaC family of ion channels… 
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