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ASIC2 protein, human

Known as: Degenerin, BNaC1, Amiloride-Sensitive Brain Sodium Channel 
Acid-sensing ion channel 2 (512 aa, ~58 kDa) is encoded by the human ASIC2 gene. This protein is involved in both synaptic transmission and cation… 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Transduction of mechanical stimuli by receptor cells is essential for senses such as hearing, touch and pain. Ion channels have a… 
Highly Cited
2005
Highly Cited
2005
Aims: Members of the acid sensing ion channel (ASIC) family are strong candidates as mechanical transducers in sensory function… 
Highly Cited
2004
Highly Cited
2004
The molecular basis of mechanosensory transduction by primary sensory neurones remains poorly understood. Amongst candidate… 
Review
2002
Review
2002
The recently discovered epithelial sodium channel (ENaC)/degenerin (DEG) gene family encodes sodium channels involved in various… 
Highly Cited
2002
Highly Cited
2002
Acidic extracellular solution activates transient H+-gated currents in dorsal root ganglion (DRG) neurons. The biophysical… 
Highly Cited
2001
Highly Cited
2001
Cardiac afferents are sensory neurons that mediate angina, pain that occurs when the heart receives insufficient blood supply for… 
Highly Cited
1998
Highly Cited
1998
Proton-gated channels expressed by sensory neurons are of particular interest because low pH causes pain. Two proton-gated… 
Highly Cited
1997
Highly Cited
1997
Proton-gated cation channels are acid sensors that are present in both sensory neurons and in neurons of the central nervous… 
Highly Cited
1996
Highly Cited
1996
Mutations of the degenerins (deg-1, mec-4, mec-10) are the major known causes of hereditary neurodegeneration in the nematode… 
Highly Cited
1994
Highly Cited
1994
GENETIC screening has identified a group ofmec (mechanosensory) genes that are required for the function of a set of six touch…