Acid Sensing Ion Channels

Known as: Proton Gated Sodium Channels, ASIC Channel, Acid Sensing Ion Channels [Chemical/Ingredient] 
A family of proton-gated sodium channels that are primarily expressed in neuronal tissue. They are AMILORIDE-sensitive and are implicated in the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Polypeptide toxins have played a central part in understanding physiological and physiopathological functions of ion channels. In… (More)
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Highly Cited
2011
Highly Cited
2011
Iatrogenic pain consecutive to a large number of surgical procedures has become a growing health concern. The etiology and… (More)
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Highly Cited
2009
Highly Cited
2009
Acid-sensing ion channels are proton-activated, sodium-selective channels composed of three subunits, and are members of the… (More)
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Highly Cited
2004
Highly Cited
2004
Ca2+ toxicity remains the central focus of ischemic brain injury. The mechanism by which toxic Ca2+ loading of cells occurs in… (More)
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Highly Cited
2004
Highly Cited
2004
Acid-sensing ion channels (ASICs), a novel class of ligand-gated cation channels activated by protons, are highly expressed in… (More)
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Highly Cited
2003
Highly Cited
2003
High grade glioma cells derived from patient biopsies express an amiloride-sensitive sodium conductance that has properties… (More)
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Highly Cited
2002
Highly Cited
2002
Tissue acidosis is an important feature of inflammation. It is a direct cause of pain and hyperalgesia. Protons activate sensory… (More)
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Highly Cited
2002
Highly Cited
2002
Many painful inflammatory and ischemic conditions such as rheumatoid arthritis, cardiac ischemia, and exhausted skeletal muscles… (More)
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Highly Cited
2001
Highly Cited
2001
Nonsteroid anti-inflammatory drugs (NSAIDs) are major drugs against inflammation and pain. They are well known inhibitors of… (More)
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Highly Cited
1997
Highly Cited
1997
MDEG1 is a cation channel expressed in brain that belongs to the degenerin/epithelial Na+ channel superfamily. It is activated by… (More)
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