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ASIC2 gene

Known as: degenerin, BNaC1, Acid-Sensing (Proton-Gated) Ion Channel 2 Gene 
This gene is involved in both cation transport and membrane potential.
National Institutes of Health

Related topics

Related topics

10 relations
ASIC2 protein, humanDegenerin Sodium ChannelsHomo sapiensIonophore activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Hyperactivation of the Mammalian Degenerin MDEG Promotes Caspase-8 Activation and Apoptosis*♦
Background: Hyperactivation of DEG/ENaC channels leads to cell death; however, the underlying mechanism for the cytotoxicity… 
Highly Cited
2008
Highly Cited
2008
Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach–brainstem axis
2007
2007
Proton binding sites involved in the activation of acid-sensing ion channel ASIC2a
2007
2007
17p11.2p12 triplication and del(17)q11.2q12 in a severely affected child with dup(17)p11.2p12 syndrome
Multiple congenital anomalies/mental retardation syndromes due to genomic rearrangements involving chromosome 17p11.2 include… 
2005
2005
The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability
Highly Cited
2004
Highly Cited
2004
Acid-Sensing Ion Channel-2 Is Not Necessary for Sour Taste in Mice
The acid-sensitive cation channel acid-sensing ion channel-2 (ASIC2) is widely believed to be a receptor for acid (sour) taste in… 
Highly Cited
2004
Highly Cited
2004
Acid-Sensing Ion Channel 2 Contributes a Major Component to Acid-Evoked Excitatory Responses in Spiral Ganglion Neurons and Plays a Role in Noise Susceptibility of Mice
Ion channels in the degenerin-epithelial sodium channel (DEG-ENaC) family perform diverse functions, including mechanosensation… 
Highly Cited
2003
Highly Cited
2003
ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons.
The acid-sensing ion channels (ASICs) form cation channels that are transiently activated by extracellular protons. They are… 
2003
2003
Immunolocalization of the acid-sensing ion channel 2a in the rat cerebellum
The acid-sensing ion channels (ASICs) are members of the DEG/ENaC superfamily of Na+ channels. Acid-gated cation currents have… 
Highly Cited
1999
Highly Cited
1999
A stomatin and a degenerin interact to control anesthetic sensitivity in Caenorhabditis elegans.
The mechanism of action of volatile anesthetics is unknown. In Caenorhabditis elegans, mutations in the gene unc-1 alter… 
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