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Neuroprotection in Ischemia Blocking Calcium-Permeable Acid-Sensing Ion Channels
Ca2+ toxicity remains the central focus of ischemic brain injury. The mechanism by which toxic Ca2+ loading of cells occurs in the ischemic brain has become less clear as multiple human trials ofExpand
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Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
CYSTIC fibrosis transmembrane conductance regulator (CFTR) is a plasma membrane Cl− channel regulated by cyclic AMP-dependent phosphorylation and by intracellular ATP1–7. Mutations in CFTR causeExpand
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Acid-sensing ion channels: advances, questions and therapeutic opportunities
Extracellular acid can have important effects on neuron function. In central and peripheral neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular protons, andExpand
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The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
Many central neurons possess large acid-activated currents, yet their molecular identity is unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents inExpand
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Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
Michael J. Welsh’ and Alan E. Smith+ ‘ Howard Hughes Medical Institute Departments of Internal Medicine and of Physiology and Biophysics University of Iowa College of Medicine Iowa City, Iowa 52242Expand
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Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a.
Acid-sensing ion channel (ASIC) 1a subunit is expressed in synapses of central neurons where it contributes to synaptic plasticity. However, whether these channels can conduct Ca(2+) and therebyExpand
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Demonstration that CFTR is a chloride channel by alteration of its anion selectivity.
Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) generates adenosine 3',5'-monophosphate (cAMP)-regulated chloride channels, indicating that CFTR is either a chlorideExpand
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Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
The bacterium Pseudomonas aeruginosa permanently colonizes cystic fibrosis lungs despite aggressive antibiotic treatment. This suggests that P. aeruginosa might exist as biofilms—structuredExpand
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A component of innate immunity prevents bacterial biofilm development
Antimicrobial factors form one arm of the innate immune system, which protects mucosal surfaces from bacterial infection. These factors can rapidly kill bacteria deposited on mucosal surfaces andExpand
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A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of
The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na+/H+ exchange. NHERF contains two PDZ domains, theExpand
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