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Neuroprotection in Ischemia Blocking Calcium-Permeable Acid-Sensing Ion Channels
TLDR
It is shown that acidosis activates Ca2+ -permeable acid-sensing ion channels (ASICs), inducing glutamate receptor-independent, Ca2-dependent, neuronal injury inhibited by ASIC blockers, and disclosing new potential therapeutic targets for stroke. Expand
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
TLDR
It is shown that the processing of CFTRΔF508 reverts towards that of wild-type as the incubation temperature is reduced, and when the processing defect is corrected, cAMP-regulated Cl− channels appear in the plasma membrane. Expand
Acid-sensing ion channels: advances, questions and therapeutic opportunities
TLDR
Advances in understanding of acid-sensing ion channels, their potential contributions to disease, and the possibility for their therapeutic modification are reviewed. Expand
The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
TLDR
It is found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents in hippocampal neurons, and null mice displayed defective spatial learning and eyeblink conditioning. Expand
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
TLDR
Cystic fibrosis is a regulated Cl- channel, for which structure-function relationships have begun to be established, and insight into the functions of individual domains has come from a number of studies. Expand
Demonstration that CFTR is a chloride channel by alteration of its anion selectivity.
TLDR
Exression of the cystic fibrosis transmembrane conductance regulator generates adenosine 3',5'-monophosphate (cAMP)-regulated chloride channels, indicating that CFTR is a cAMP-regulated chloride channel and that lysines 95 and 335 determine anion selectivity. Expand
Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid (*)
TLDR
The results indicate that endocytosis was the major mechanism of entry in cationic lipid-mediated gene transfer and suggest that attention to specific steps in the cellular process may further improve the efficiency of transfection and increase its use in a number of applications. Expand
Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a.
TLDR
It is found that extracellular acidosis opened ASIC1a channels, which provided a pathway for Ca(2+) entry and elevated [Ca(2+)](c) in wild-type, but not ASIC1(-/-), hippocampal neurons, and this results indicate that ASIC 1a provides a non-voltage-gated pathway to enter neurons. Expand
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of
TLDR
The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na-H+ exchange and may be multifunctional adaptor proteins involved in many previously unsuspected aspects of intracellular signaling. Expand
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
TLDR
The hypothesis that P. aeruginosa might exist as biofilms—structured communities of bacteria encased in a self-produced polymeric matrix—in the cystic fibrosis lung is supported by microscopy of cystic Fibrosis sputum, which shows that the bacterium are in biofilm-like structures. Expand
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