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ARHGEF18 gene

Known as: KIAA0521, RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 18, Rho/Rac guanine nucleotide exchange factor 18 
National Institutes of Health

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ARHGEF17 gene

Papers overview

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2015
2015
p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK–myosin-II pathway
ABSTRACT Tubulogenesis is fundamental to the development of many epithelial organs. Although lumen formation in cysts has… 
2013
2013
ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation
The vertebrate central nervous system develops from an epithelium where cells are polarized along the apicobasal axis. Loss of… 
2013
2013
Expression of p114RhoGEF predicts lymph node metastasis and poor survival of squamous-cell lung carcinoma patients
The Rho-specific guanine nucleotide exchanging factor p114RhoGEF is involved in RhoA activation and cell motility. Previous… 
Review
2013
Review
2013
ArhGEF18 regulated Rho signaling in vertebrate retina development
Epithelia consisting of highly polarized columnar cells contribute to many organs during development, including the central… 
2012
2012
Stimulation of Cortical Myosin Phosphorylation by p114RhoGEF Drives Cell Migration and Tumor Cell Invasion
Actinomyosin activity is an important driver of cell locomotion and has been shown to promote collective cell migration of… 
2012
2012
The circumferential actomyosin belt in epithelial cells is regulated by the Lulu2-p114RhoGEF system
In epithelial cells, myosin-II-dependent forces regulate many aspects of animal morphogenesis, such as apical constriction, cell… 
Review
2011
Review
2011
Possible Involvement of Tight Junctions, Extracellular Matrix and Nuclear Receptors in Epithelial Differentiation
Tight junctions are intercellular junctions localized at the most apical end of the lateral plasma membrane. They consist of four… 
2010
2010
Involvement of p114-RhoGEF and Lfc in Wnt-3a– and Dishevelled-Induced RhoA Activation and Neurite Retraction in N1E-115 Mouse Neuroblastoma Cells
We screened for Rho-GEF-silencing shRNAs that are capable of suppressing Dishevelled (Dvl)-induced neurite retraction in N1E-115… 
2003
2003
G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.
Rho GTPases integrate the intracellular signaling in a wide range of cellular processes. Activation of these G proteins is… 
2001
2001
A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2.
Mutations in MCOLN1 have been found to cause mucolipidosis type IV (MLIV; MIM 252650), a rare autosomal recessive lysosomal… 
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