ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation.

@article{Herder2013ArhGEF18RR,
  title={ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation.},
  author={Cathrin Herder and Jakub M. Swiercz and Claudia Mueller and Ravindra Peravali and Rebecca Quiring and Stefan Offermanns and Joachim Wittbrodt and Felix Loosli},
  journal={Development},
  year={2013},
  volume={140 13},
  pages={2787-97}
}
The vertebrate central nervous system develops from an epithelium where cells are polarized along the apicobasal axis. Loss of this polarity results in abnormal organ architecture, morphology and proliferation. We found that mutations of the guanine nucleotide exchange factor ArhGEF18 affect apicobasal polarity of the retinal neuroepithelium in medaka fish. We show that ArhGEF18-mediated activation of the small GTPase RhoA is required to maintain apicobasal polarity at the onset of retinal… CONTINUE READING
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