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AR-C239
Known as:
ARC 239
, AR C239
, AR-C 239
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Adrenergic alpha-Antagonists
Isoquinolines
Piperazines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Dexmedetomidine Protects Rat Liver against Ischemia-Reperfusion Injury Partly by the α2A-Adrenoceptor Subtype and the Mechanism Is Associated with the TLR4/NF-κB Pathway
Yiheng Wang
,
Shan Wu
,
+4 authors
Jun Cai
International Journal of Molecular Sciences
2016
Corpus ID: 17659239
Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling plays a dominant role in the pathogenesis of liver ischemia…
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2015
2015
Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling
Xinjin Chi
,
Xiaoxia Wei
,
+5 authors
Jun Cai
Journal of Translational Medicine
2015
Corpus ID: 14812266
BackgroundTo investigate whether pretreatment with dexmedetomidine (Dex) has a protective effect against acute lung injury (ALI…
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2004
2004
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype
N. Galeotti
,
A. Bartolini
,
C. Ghelardini
Behavioural Brain Research
2004
Corpus ID: 24644245
Highly Cited
2002
Highly Cited
2002
Alcohol-Induced c-Fos Expression in the Edinger-Westphal Nucleus: Pharmacological and Signal Transduction Mechanisms
R. Bachtell
,
N. Tsivkovskaia
,
A. Ryabinin
Journal of Pharmacology and Experimental…
2002
Corpus ID: 12875329
Mapping inducible transcription factors has shown that the Edinger-Westphal nucleus is preferentially sensitive to alcohol…
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Highly Cited
2000
Highly Cited
2000
Silent alpha(2C)-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries.
M. Chotani
,
S. Flavahan
,
S. Mitra
,
D. Daunt
,
N. Flavahan
American Journal of Physiology. Heart and…
2000
Corpus ID: 1253804
Cold constricts cutaneous blood vessels by increasing the reactivity of smooth muscle alpha(2)-adrenergic receptors (alpha(2)-ARs…
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Highly Cited
1996
Highly Cited
1996
Different alpha-adrenoceptor subtypes mediate constriction of arterioles and venules.
C. Leech
,
J. Faber
American Journal of Physiology
1996
Corpus ID: 46121595
Recent studies indicate that rat vascular smooth muscle can express mRNAs for the alpha 1A-(alpha 1c-), alpha 1B-, alpha 1D…
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Highly Cited
1990
Highly Cited
1990
Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia.
I. Angel
,
R. Niddam
,
S. Z. Langer
Journal of Pharmacology and Experimental…
1990
Corpus ID: 21785350
Alpha-2 adrenoceptor stimulation induces in the mouse a hyperglycemic response which is accompanied by a concomitant inhibition…
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Highly Cited
1989
Highly Cited
1989
Alpha-2A and alpha-2B adrenergic receptor subtypes: attenuation of cyclic AMP production in cell lines containing only one receptor subtype.
D. Bylund
,
C. Ray-Prenger
Journal of Pharmacology and Experimental…
1989
Corpus ID: 45934237
At least two subtypes of alpha-2 adrenergic receptors have been identified on the basis of antagonist affinities as determined…
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Highly Cited
1988
Highly Cited
1988
Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype.
D. Bylund
,
C. Ray-Prenger
,
T. J. Murphy
Journal of Pharmacology and Experimental…
1988
Corpus ID: 22246360
The affinities of 34 adrenergic antagonists for alpha-2 adrenergic receptors were determined from homogenate radioligand binding…
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1980
1980
Pharmacological properties of AR-C239, 2-[2-[4(o-methoxyphenyl)-piperazine-1-Yl]-ethyl]4,4-dimethyl-1,3(2H-4H) isoquinolinedione, a new alpha-adrenoceptor blocking drug.
P. Mouille
,
A. Huchet
,
J. Chelly
,
B. Lucet
,
M. Doursout
,
H. Schmitt
Journal of Cardiovascular Pharmacology
1980
Corpus ID: 32084840
In pentobarbital-treated dogs and rats, AR-C239, a new and potent alpha-adrenoceptor blocking drug, competitively antagonized…
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