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The Cytolytic P2Z Receptor for Extracellular ATP Identified as a P2X Receptor (P2X7)
The P2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Other ATP-gated channels, the P2XExpand
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Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
P2X7 receptors are ATP‐gated cation channels; their activation in macrophage also leads to rapid opening of a membrane pore permeable to dyes such as ethidium, and to release of the pro‐inflammatoryExpand
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Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed. All six proteins are 36–48 percent identical and seem to have two transmembrane segments with a large extracellular loop.Expand
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Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
Cation-selective P2X receptor channels were first described in sensory neurons1-4 where they are important for primary afferent neurotransmission and nociception5,6. Here we report the cloning of aExpand
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Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors.
There are few antagonists selective for subtypes of the several P2X receptors, but these are needed to identify the receptors expressed on native cells and tissues. In particular, P2X(4) and P2X(7)Expand
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Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor
The P2X7 receptor is a uniquely bifunctional molecule through which ATP can open a small cationic channel typical of ionotropic receptors and also induce a large pore permeable to high molecularExpand
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An antagonist‐insensitive P2X receptor expressed in epithelia and brain.
A cDNA was cloned which encodes a new ATP‐gated ion channel (P2X4 receptor). ATP induces a cationic current in HEK293 cells transfected with the P2X4 receptor. However, the current is almostExpand
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Signaling at purinergic P2X receptors.
P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X(1-7)) are widely distributed in excitable and nonexcitable cells of vertebrates. They play keyExpand
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Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors.
There are currently seven P2X receptor subunits (P2X1-7) defined by molecular cloning. The functional identification of these receptors has relied primarily on the potency of alpha,beta-methylene-ATPExpand
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P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1β in Mouse Macrophage1
The proinflammatory IL-1 cytokines IL-1α, IL-1β, and IL-18 are key mediators of the acute immune response to injury and infection. Mechanisms underlying their cellular release remain unclear.Expand
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