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APO 866

Known as: APO-866, APO866, NMPRTase Inhibitor APO866 
National Institutes of Health

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2 relations

Broader (2)

DaporinadEnzyme Inhibitors

Papers overview

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2016
2016
Induction of Apoptosis and Autophagy By Nampt Inhibition in Adult T-Cell Leukemia/Lymphoma and Leukemic Cell Lines
Introduction: Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T-cell neoplasm that develops after long-term… 
2015
2015
Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation.
2015
2015
A multicenter, open label, phase II study to assess the efficacy and safety of APO866 in the treatment of patients with refractory or relapsed cutaneous T-cell lymphoma.
e20044 Background: Cutaneous T-cell lymphoma (CTCL) is characterized by the accumulation of clonal T-cells in the skin. Given the… 
2014
2014
NAD⁺ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study.
2014
2014
The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody
Abstract APO866 is an inhibitor of nicotinamide adenine dinucleotide (NAD) biosynthesis that exhibits potent anti-lymphoma… 
2013
2013
[18F]FLT and [18F]FDG PET for Non-invasive Treatment Monitoring of the Nicotinamide Phosphoribosyltransferase Inhibitor APO866 in Human Xenografts
Introduction APO866 is a new anti-tumor compound inhibiting nicotinamide phosphoribosyltransferase (NAMPT). APO866 has an anti… 
2013
2013
AB0131 NAMPT/VISFATIN in osteoarthritis: An adipokine involved in the communication between cartilage and bone
Background It has been recently demonstrated that a pro-inflammatory adipokine called visfatin can be produced by chondrocytes in… 
2012
2012
74 Synergistic Interaction Between P-glycoprotein Inhibitors and APO866 in Primary Leukemic Cells
2011
2011
Pre-B Cell Colony-Enhancing Factor (PBEF/Nampt/Visfatin) Primes Neutrophils for Augmented Respiratory Burst Activity through Partial Assembly of the NADPH Oxidase
Pre-B cell colony-enhancing factor ([PBEF] also known as Nampt/visfatin) is a pleiotropic 52-kDa cytokine-like molecule whose… 
2009
2009
Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT.
To the editor: We read with interest the elegant studies of Koyama and colleagues[1][1] in which they demonstrate the ability of… 
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