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APO 866

Known as: APO-866, APO866, NMPRTase Inhibitor APO866 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
IntroductionNerve growth factor (NGF) level is increased in osteoarthritis (OA) joints and is involved in pain associated with OA… Expand
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2014
2014
IntroductionVisfatin is an adipokine that may be involved in intertissular joint communication in osteoarthritis (OA). With a… Expand
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2012
2012
Visfatin (also termed pre-B-cell colony-enhancing factor (PBEF) or nicotinamide phosphoribosyltransferase (Nampt)) is a… Expand
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Review
2012
Review
2012
Nampt/Visfatin/PBEF is a primary, rate-limiting enzyme involved in NAD+ biosynthesis, which serves as a pivotal substance for… Expand
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2011
2011
OBJECTIVE To assess the ability of pre-B cell colony-enhancing factor (PBEF) to regulate inflammation and degradative processes… Expand
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2011
2011
Visfatin, also known as extracellular pre–B-cell colony–enhancing factor (PBEF) and nicotinamide phosphoribosyltransferase (Nampt… Expand
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2010
2010
OBJECTIVE The nicotinamide phosphoribosyltransferase (Nampt) inhibitor APO866 depletes intracellular nicotinamide adenine… Expand
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2010
2010
Many types of malignant cells have a higher nicotinamide adenine dinucleotide (NAD) turnover rate than normal cells, as well as… Expand
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Highly Cited
2009
Highly Cited
2009
Aims/hypothesisExtracellular pre-B cell colony-enhancing factor/nicotinamide phosphoribosyltransferase/visfatin (ePBEF/NAMPT… Expand
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Highly Cited
2009
Highly Cited
2009
APO866 inhibits nicotinamide phosphoribosyltransferase (NMPRTase), a key enzyme involved in nicotinamide adenine dinucleotide… Expand
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