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Daporinad

Known as: (2E)-N-(4-(1-Benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)prop-2-enamide 
A small molecule with potential antineoplastic and antiangiogenic activities. Daporinad binds to and inhibits nicotinamide phosphoribosyltransferase… 
National Institutes of Health

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APO 866

Papers overview

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2018
2018
Abstract 3515: Down the rabbit hole with structural effects of FK866 in primary CLL B cells
FK866 (Daporinad or APO866) is a specific inhibitor of NAMPT (nicotinamide phosphoribosyltransferase), a rate limiting enzyme… 
2018
2018
Abstract LB-099: Metabolic vulnerabilities of mesenchymal-like EGFR-mutant NSCLC cells with acquired resistance to tyrosine kinase inhibitors
Despite the availability of the effective targeted therapies in lung cancer, such as EGFR tyrosine kinase inhibitors (TKIs), drug… 
2017
2017
Análisis genómico funcional de la resistencia a las terapias anti-egfr asociada al fenotipo mesenquimal en el cáncer pulmonar
Lung cancer is the leading cause of cancer death in western countries. It is highly resistant to the conventional therapy… 
2017
2017
Abstract 2478: PARP trapping by PARP inhibitors have distinct effects on HR and ALT NHEJ DSB repair, potentially impacting its therapeutic efficacy in breast cancers
PARP inhibitors (PARPi) have exhibited clinical success in inherited breast cancers with mutations in homologous recombination… 
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