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Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization
A biosensor developed to study the subcellular distribution of phosphatidylserine found that it binds the cytosolic leaflets of the plasma membrane, as well as endosomes and lysosomes. Expand
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis.
PBEF is identified as a novel inflammatory cytokine that plays a requisite role in the delayed neutrophil apoptosis of clinical and experimental sepsis and is also upregulated in neutrophils by IL-1beta and functions as an inhibitor of apoptosis in response to a variety of inflammatory stimuli. Expand
Receptor Activation Alters Inner Surface Potential During Phagocytosis
These probes revealed marked, localized alterations in the charge of the inner surface of the plasma membrane of macrophages during the course of phagocytosis, which accounted for the change in surface potential at the phagosomal cup. Expand
Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.
Osmotic inhibition of NHE-3 may play a role in the physiology and pathophysiology of epithelia and contribute to intracellular pH (pHi) homeostasis and have a permissive role in cell growth. Expand
Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin.
It is shown that TGF-beta 1 was unable to induce EMT in intact confluent monolayers, but three different models of injury-induced loss of epithelial integrity restored its EMT-inducing effect, suggesting a beta-catenin-dependent two-hit mechanism in which both an initial epithelial injury and TGF 1 are required for EMT. Expand
Fyn and p38 Signaling Are Both Required for Maximal Hypertonic Activation of the Osmotic Response Element-binding Protein/Tonicity-responsive Enhancer-binding Protein (OREBP/TonEBP)*
  • B. Ko, A. Lam, A. Kapus, Lingzhi Fan, Sookja K. Chung, Stephen S. M. Chung
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 29 November 2002
It is shown that the transactivation domain of OREBP/TonEBP is the target of p38- and Fyn-mediated hypertonic activation, indicating a dual control in regulating the expression of the osmoprotective genes in mammalian cells. Expand
Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling.
Whereas individual components of the CAP to TC10 pathway are regulated by insulin, a functional TC10-dependent signaling pathway leading to actin remodeling and GLUT4 translocation may not operate in myocytes, as it does in adipocytes. Expand
Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition.
Rho plays a dual role in TGF-beta(1)-induced EMT of renal epithelial cells, indispensable both for cytoskeleton remodeling and for the activation of the SMA promoter. Expand
GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.
The ERK/GEF-H1/Rho/ Rho kinase/phospho-MLC pathway is identified as the mechanism mediating TNF-alpha-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury. Expand
Force activates smooth muscle α-actin promoter activity through the Rho signaling pathway
Mechanical forces mediate actin assembly through the Rho–Rho-kinase–LIMK cofilin pathway, which promotes nuclear translocation of MRTF and subsequent activation of the SMA promoter to enhance SMA expression in fibroblasts. Expand