ANK1 gene

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by progressive neuropathology and… (More)

Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces early-developing, painful, and cold… (More)

Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested… (More)

The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional regulatory element. There are two… (More)

Transient receptor potential ankyrin 1 (TRPA1) is expressed by nociceptive neurons of the dorsal root ganglia (DRGs) and… (More)

Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has… (More)

The release of methyl isocyanate in Bhopal, India, caused the worst industrial accident in history. Exposures to industrial… (More)

Hydrogen peroxide (H(2)O(2)), which is contained in industrial products, is also generated within cells. H(2)O(2) causes pain but… (More)

Tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes the mineralization inhibitor inorganic pyrophosphate (PP(i)). Deletion… (More)

Many proteins rely on stable, noncovalent interactions with other macromolecules to perform their function. The identification of… (More)