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AMD 473

Known as: AMD-473, AMD473 
National Institutes of Health

Related topics

Related topics

2 relations
JM-473

Broader (1)

Picoplatin

Papers overview

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Highly Cited
2006
Highly Cited
2006
Thermodynamic and kinetic studies on reactions of Pt(II) complexes with biologically relevant nucleophiles.
The effect of different N-N spectator ligands on the reactivity of platinum(II) complexes was investigated by studying the water… 
2006
2006
Platinum(IV) analogues of AMD473 (cis-[PtCl2(NH3)(2-picoline)]): preparative, structural, and electrochemical studies.
The preparation and oxidation of the anticancer drug AMD473, cis-[PtCl2(NH3)(2-pic)] (2-pic = 2-methylpyridine), has been… 
2006
2006
Synthesis, characterisation, activities, cell uptake and DNA binding of a trinuclear complex: [[trans-PtCl(NH3)]2mu-[trans-Pd(NH3)(2-hydroxypyridine)-(H2)N(CH2)6NH2)2]Cl4.
Highly Cited
2005
Highly Cited
2005
Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells
Platinum-based chemotherapeutic regimens are ultimately unsuccessful due to intrinsic or acquired drug resistance. Understanding… 
Highly Cited
2005
Highly Cited
2005
Contrasting chemistry of cis- and trans-platinum(II) diamine anticancer compounds: hydrolysis studies of picoline complexes.
cis-[PtCl2(NH3)(2-picoline)] (AMD473) is currently on clinical trials as an anticancer drug. The trans isomer, AMD443 (1), is… 
Highly Cited
2000
Highly Cited
2000
Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines.
Highly Cited
1998
Highly Cited
1998
In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473.
A novel sterically hindered platinum complex, AMD473 [cis-aminedichloro(2-methylpyridine) platinum (II)], has been selected for… 
Highly Cited
1998
Highly Cited
1998
Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis-[amminedichloro(2-methylpyridine)] platinum(II) (AMD473).
cis-[Amminedichloro(2-methylpyridine)] platinum(II) (AMD473) is a novel sterically hindered anti-tumour compound designed to… 
1998
1998
Characterisation of the P53 status, BCL‐2 expression and radiation and platinum drug sensitivity of a panel of human ovarian cancer cell lines
The P53gene is frequently mutated in late stage ovarian cancer and has been proposed as a determinant of radiation and… 
Highly Cited
1997
Highly Cited
1997
cis-Amminedichloro(2-methylpyridine) platinum(II) (AMD473), a novel sterically hindered platinum complex: in vivo activity, toxicology, and pharmacokinetics in mice.
A novel sterically hindered platinum complex, AMD473 [cis-amminedichloro(2-methylpyridine) platinum(II)], designed primarily to… 
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