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Synthesis, structure, and spectroscopic properties of copper(II) compounds containing nitrogen–sulphur donor ligands; the crystal and molecular structure of
The linear quadridentate N2S2 donor ligand 1,7-bis(N-methylbenzimidazol-2′-yl)-2,6-dithiaheptane (bmdhp) forms mono- and di-hydrate 1 : 1 copper(II) complexes which are significantly more stableExpand
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Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation.
Salmon sperm DNA, treated with the antitumor agent cis-diamminedichloroplatinum(II) (cis-DDP), was enzymatically degraded to (oligo)nucleotides. Four Pt-containing products were identified by 1H NMRExpand
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New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA
  • J. Reedijk
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 24 March 2003
From the metal ions and metal compounds that are known to bind to DNA, many anticancer Pt(II) and Ru(II)/Ru(III) compounds are known to have ligand-exchange kinetics in the same order of magnitude asExpand
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Structure and isomerization of an intrastrand cisplatin-cross-linked octamer DNA duplex by NMR analysis.
The anticancer platinum compound cis-Pt(NH3)2Cl2 (cisplatin) forms covalent cross-linked adducts with DNA, with the intrastrand didentate adduct between two adjacent guanines being the major product.Expand
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Why does Cisplatin reach Guanine-n7 with competing s-donor ligands available in the cell?
  • J. Reedijk
  • Chemistry, Medicine
  • Chemical reviews
  • 21 August 1999
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The mechanism of action of platinum antitumor drugs
A discussion is presented on the mechanism of action of platinum amine compounds, used as antitumor drugs. The relationship between biological acitivity and structure of the compounds is discussed,Expand
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Is the impact of journal impact factors decreasing?
A critical examination of the manipulability of the citation‐based journal impact factor on the basis of an empirical analysis of publication and referencing practices of authors and journal editors . Expand
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A new classification system to describe the ageing of scientific journals and their impact factors
In this article, ageing patterns are examined in ‘formal’ use or impact of all scientific journals processed for the Science Citation Index (SCI) during 1981‐1995. Expand
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Formation and repair of cisplatin-induced adducts to DNA in cultured normal and repair-deficient human fibroblasts.
The formation and repair of cisplatin [cis-PtCl2(NH3)2] adducts in the DNA of cultured normal and repair-deficient human fibroblasts are presented in relation to cell survival after cisplatinExpand
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