Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines.

@article{Holford2000MechanismsOD,
  title={Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines.},
  author={John Holford and Philip J. Beale and Frances E. Boxall and Swee Y. Sharp and Lloyd R. Kelland},
  journal={European journal of cancer},
  year={2000},
  volume={36 15},
  pages={
          1984-90
        }
}
Acquired drug resistance to the sterically hindered platinum drug ZD0473 (formerly known as JM473 and AMD473) and currently being tested in phase I clinical trials, has been studied in two human ovarian carcinoma cell lines (CH1 and A2780) where previously, acquired cisplatin resistance has been described. Common mechanisms of resistance were observed in A2780 acquired cisplatin and ZD0473R (resistant) lines (including reduced drug transport and DNA platination, increased glutathione (GSH) and… CONTINUE READING

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