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ALT 711

Known as: 711 alt, ALT-711, ALT711 
National Institutes of Health

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Broader (1)

alagebrium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Alagebrium targets the miR-27b/TSP-1 signaling pathway to rescue Nε-carboxymethyl-lysine-induced endothelial dysfunction.
Nε-carboxymethyl-lysine (CML), a major isoform of advanced glycation end products (AGEs), plays a crucial role in the functional… 
2014
2014
AGEs breaking and antioxidant treatment improves endothelium-dependent dilation without effect on flow-mediated remodeling of resistance arteries in old Zucker diabetic rats
BackgroundA chronic increase in blood flow in resistance arteries is associated with increased lumen diameter (outward remodeling… 
2014
2014
Alagebrium (ALT-711) improves the anti-hypertensive efficacy of nifedipine in diabetic-hypertensive rats
Combining drugs with complementary mechanisms of action may contribute to improved hypertension control in diabetic patients… 
2011
2011
The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase.
Advanced glycation end products (AGEs) are involved in age-related diseases, including the complications of diabetes and chronic… 
2010
2010
Aldose reductase inhibition ameliorates the detrimental effect of estrogen replacement therapy on neuropathology in diabetic rats subjected to transient forebrain ischemia
2009
2009
Letter by Hartog et al. regarding article, "Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines".
We thank Dr Hartog and colleagues for their interest in our study1 and agree with their conclusion that other advanced glycation… 
2009
2009
The Thiamine Analogue and Advanced Glycation Endproducts Crosslink Breaker ALT-711 does not Interfere with Transketolase Activity
The enzyme transketolase (sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase, EC 2.2.1.1) is… 
Review
2004
Review
2004
Crosslink breakers: a new approach to cardiovascular therapy
Purpose of review Advanced glycation end-products accumulate on body proteins with aging, and their formation is greatly enhanced… 
Review
2001
Review
2001
ALT-711 decreases cardiovascular stiffness and has potential in diabetes, hypertension and heart failure
Vascular and/or myocardial stiffness is a major problem in ageing, diabetes, hypertension and heart failure. The development of… 
2000
2000
Improvement by aminoguanidine of insulin secretion from pancreatic islets grafted to syngeneic diabetic rats.
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