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alagebrium

Known as: 3-phenacyl-4,5-dimethylthiazolium chloride, phenyl-4,5-dimethylthiazolium chloride 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

ALT 711

Broader (1)

Thiazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Alagebrium targets the miR-27b/TSP-1 signaling pathway to rescue Nε-carboxymethyl-lysine-induced endothelial dysfunction.
Nε-carboxymethyl-lysine (CML), a major isoform of advanced glycation end products (AGEs), plays a crucial role in the functional… 
2016
2016
Encapsulation of AGE-Breaker Alagebrium by Cucurbit[7]uril Improved the Stability of Both Its Carbonyl α-Hydrogen and Thiazolium C2-Hydrogen.
As determined by both 1 H NMR and UV/Vis spectroscopic titration, ESI-MS, isothermal titration calorimetry, and DFT molecular… 
2016
2016
The effect of 1 year of Alagebrium and moderate-intensity exercise training on left ventricular function during exercise in seniors: a randomized controlled trial.
Sedentary aging leads to left ventricular (LV) and vascular stiffening due in part to advanced glycation end-products (AGEs… 
2014
2014
Alagebrium (ALT-711) improves the anti-hypertensive efficacy of nifedipine in diabetic-hypertensive rats
Combining drugs with complementary mechanisms of action may contribute to improved hypertension control in diabetic patients… 
Review
2014
Review
2014
231 Circulation : Heart Failure Topic Review Cardiovascular Effects of 1 Year of Alagebrium and Endurance Exercise Training in Healthy Older Individuals
Lifelong exercise training maintains a youthful compliance of the left ventricle (LV), whereas a year of exercise training… 
2009
2009
Advanced glycation end-products (AGEs): a novel therapeutic target for osteoporosis in patients with rheumatoid arthritis.
2009
2009
The Breakdown of Preformed Peritoneal Advanced Glycation End Products by Intraperitoneal Alagebrium
It has been demonstrated that inhibitors of advanced glycation end products (AGE), such as aminoguanidine, can suppress… 
2006
2006
Preservation of pressure-induced cutaneous vasodilation by limiting oxidative stress in short-term diabetic mice.
2006
2006
Extracellular glycation crosslinks: prospects for removal.
Extracellular aging--accumulating molecular damage by glycation, oxidation, and crosslinking of long-lived extracellular proteins… 
Review
2005
Review
2005
The next generation of diabetic nephropathy therapies: an update.
Although treatments for diabetic kidney disease are available, many patients still have progressive disease. More effective… 
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