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ALAD gene

Known as: DELTA-AMINOLEVULINATE DEHYDRATASE, ALADH, PORPHOBILINOGEN SYNTHASE 
National Institutes of Health

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PORPHOBILINOGEN SYNTHASEPorphobilinogen

Papers overview

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Highly Cited
2007
Highly Cited
2007
Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats.
Oxidative stress is an important molecular mechanism for kidney injury in mercury poisoning. We studied lycopene, a potent… 
Highly Cited
2003
Highly Cited
2003
Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro.
Highly Cited
2001
Highly Cited
2001
The Molecular Mechanism of Lead Inhibition of Human Porphobilinogen Synthase*
Human porphobilinogen synthase (PBGS) is a main target in lead poisoning. Human PBGS purifies with eight Zn(II) per homo-octamer… 
Highly Cited
2000
Highly Cited
2000
Import of host δ-aminolevulinate dehydratase into the malarial parasite: Identification of a new drug target
The parasite Plasmodium berghei imports the enzyme δ-aminolevulinate dehydratase (ALAD), and perhaps the subsequent enzymes of… 
Highly Cited
1998
Highly Cited
1998
Effect of the delta-aminolevulinate dehydratase polymorphism on the accumulation of lead in bone and blood in lead smelter workers.
Lead inhibition of the zinc metalloenzyme delta-aminolevulinate dehydratase (ALAD) is one of the most sensitive indicators of… 
Highly Cited
1997
Highly Cited
1997
X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase
5-Aminolaevulinate dehydratase (ALAD) is a homo-octameric metallo-enzyme that catalyses the formation of porphobilinogen from 5… 
Highly Cited
1995
Highly Cited
1995
Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase.
The synthesis of tetrapyrroles is essential to all phyla. Porphobilinogen synthase (PBGS) is a zinc metalloenzyme that catalyzes… 
Highly Cited
1991
Highly Cited
1991
The delta-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes.
Highly Cited
1986
Highly Cited
1986
Human delta-aminolevulinate dehydratase: nucleotide sequence of a full-length cDNA clone.
Two cDNAs encoding human delta-aminolevulinate dehydratase (ALA-D; porphobilinogen synthase; EC 4.2.1.24), the second enzyme in… 
Highly Cited
1973
Highly Cited
1973
Fermentation of Glucose, Fructose, and Xylose by Clostridium thermoaceticum: Effect of Metals on Growth Yield, Enzymes, and the Synthesis of Acetate from CO2
Clostridium thermoaceticum ferments xylose, fructose, and glucose with acetate as the only product. In fermentations with… 
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