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MIF Signal Transduction Initiated by Binding to CD74
TLDR
It is reported herein that CD74, a Type II transmembrane protein, is a high-affinity binding protein for MIF, and it is identified as a natural ligand forCD74, which has been implicated previously in signaling and accessory functions for immune cell activation. Expand
The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor
TLDR
It is reported that cells of the monocyte/macrophage lineage are an important source of MIF in vitro and in vivo, and high levels of both preformed MIF protein and MIF mRNA in resting, nonstimulated cells are observed. Expand
Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF)
TLDR
It is indicated that the sustained activation of p44/p42 MAP kinase and subsequent arachidonate release by cytoplasmic phospholipase A2 are important features of the immunoregulatory and intracellular signaling events initiated by MIF and provide the first insight into the mechanisms that underlie the pro-proliferative and inflammatory properties of this mediator. Expand
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
TLDR
Macrophage migration inhibitory factor (MIF) is identified as a major secreted protein released by anterior pituitary cells in response to LPS stimulation, and it is concluded that MIF plays a central role in the toxic response to endotoxaemia and possibly septic shock. Expand
Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response
TLDR
Macrophage migration inhibitory factor (MIF), a product of activated macrophages, sustains macrophage survival and function by suppressing activation-induced, p53-dependent apoptosis and suggests new approaches for the modulation of innate immune responses. Expand
Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).
TLDR
These studies establish the biochemical identity of native and recombinant MIF and provide a first insight into the three-dimensional structural properties of this critical inflammatory mediator. Expand
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
TLDR
The data provide direct genetic evidence for a functional link between MIF and the p53 tumor suppressor and indicate an important and previously unappreciated role for MIF in carcinogenesis. Expand
An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect.
Cancer cells maintain a high glycolytic rate even in the presence of oxygen, a phenomenon first described over 70 years ago and known historically as the Warburg effect. Fructose 2,6-bisphosphate isExpand
The Tautomerase Active Site of Macrophage Migration Inhibitory Factor Is a Potential Target for Discovery of Novel Anti-inflammatory Agents*
TLDR
Investigation of the crystal structure of MIF complexed to (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester reveals that ISO-1 binds to the same position of the active site asp-Hydroxymylpyruvic acid, a substrate of M IF, further establishing a role for the catalytic active site of Mif. Expand
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
TLDR
In Fig. 2 legend, the orientation of the downstream primers was inadvertently reversed: the sequences are correct but they run from 5' to 3' and not from 3' to 5' as published. Expand
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