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Organoselenium and organotellurium compounds: toxicology and pharmacology.
TLDR
The development of new organochalcogens with higher thiol-peroxidase activity that can use other non-toxic thiol reducing agents, such as N-acetylcysteine instead of glutathione, will permit the investigation of the co-administration of organochAlcogens and thiols as a formulation for antioxidant therapy. Expand
Krebs Cycle Intermediates Modulate Thiobarbituric Acid Reactive Species (TBARS) Production in Rat Brain In Vitro
TLDR
Results suggest that oxaloacetate, malate, succinate, and citrate are effective antioxidants against basal and iron or QA-induced TBARS production, while α-ketoglutarate stimulatesTBARS production. Expand
Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice.
TLDR
It is shown that ascorbic acid can reverse some alterations caused by in vivo selenium exposure, but not ALA-D inhibition, and this study suggests that vitamin C may have a protective role in organodiselenide intoxication. Expand
Chlorpyrifos acute exposure induces hyperglycemia and hyperlipidemia in rats.
TLDR
It is demonstrated that a single CPF administration caused hyperglycemia and hyperlipidemia in rats and the activation of the gluconeogenesis pathway, probably elicited by hypercorticosteronemia, is involved in the hyperglycemic effect of CPF in rats. Expand
Candida dubliniensis: Epidemiology and Phenotypic Methods for Identification
TLDR
In this article, the various phenotypic methods used in the identification of C. dubliniensis are reviewed and the epidemiological impact of this new species is reviewed. Expand
Anti-inflammatory and antinociceptive activity of diphenyl diselenide
TLDR
Evidence is provided that administration of diphenyl diselenide produced anti-inflammatory and antinociceptive activity, significantly higher than ebselen. Expand
Diphenyl diselenide and diphenyl ditelluride affect the rat glutamatergic system in vitro and in vivo
TLDR
The results suggest that the toxic effects of organochalcogens could result from action at different levels of neural signal transduction pathways, possibly involving other neurotransmitters besides the glutamatergic system. Expand
Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds
TLDR
The potential therapeutic use of simple organoselenium compounds has not yet been sufficiently explored and this class of compounds cannot discard as promising pharmaceutical agents, in effect, the future of the organochalcogens as pharmacological agents will depend on more detailed toxicological studies in the oncoming years. Expand
Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice.
TLDR
The present study provides evidence for liver and renal toxicity of (PhTe)(2) as well as potential toxic effects of diphenyl diselenide, Diphenyl ditelluride and Ebselen in rats and mice. Expand
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