AICDA gene

Known as: AID, CDA2, Activation-Induced Cytidine Deaminase Gene 
This gene plays a role in both class-switch recombination in B-lymphocytes and cytidine deamination.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
To elucidate the specific role of somatic hypermutation (SHM) in mucosal immunity, we generated mice carrying a knock-in point… (More)
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Highly Cited
2011
Highly Cited
2011
Immunologists and evolutionary biologists have been debating the nature of the immune system of jawless vertebrates—lampreys and… (More)
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Highly Cited
2008
Highly Cited
2008
Morphologically and functionally distinct subpopulations of human memory B (B(Mem)) cells are identifiable by either their… (More)
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Review
2008
Review
2008
Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals. It occurs by a… (More)
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2006
2006
Somatic hypermutation and class switch recombination of immunoglobulin genes are dependent on the presence of the activation… (More)
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Highly Cited
2005
Highly Cited
2005
IL-21 is a type I cytokine that influences the function of T cells, NK cells, and B cells. In this study, we report that IL-21… (More)
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Highly Cited
2004
Highly Cited
2004
A feature of Ig hypermutation is the presence of hypermutable DNA sequences that are preferentially found in the V regions of Ig… (More)
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2004
2004
In response to activation by WASP-family proteins, the Arp2/3 complex nucleates new actin filaments from the sides of preexisting… (More)
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Highly Cited
2004
Highly Cited
2004
The synthesis of high affinity antibodies requires activation-induced cytidine deaminase (AID) to initiate somatic hypermutation… (More)
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Highly Cited
2003
Highly Cited
2003
Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided a comprehensive picture of immune… (More)
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