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AICDA gene

Known as: AID, CDA2, Activation-Induced Cytidine Deaminase Gene 
This gene plays a role in both class-switch recombination in B-lymphocytes and cytidine deamination.
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
We applied a fusion of CRISPR-Cas9 and activation-induced cytidine deaminase (Target-AID) for point mutagenesis at genomic… Expand
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Highly Cited
2011
Highly Cited
2011
Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These… Expand
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Highly Cited
2011
Highly Cited
2011
To elucidate the specific role of somatic hypermutation (SHM) in mucosal immunity, we generated mice carrying a knock-in point… Expand
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Highly Cited
2011
Highly Cited
2011
The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, leading to tumorigenesis. The extent… Expand
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Highly Cited
2009
Highly Cited
2009
Jawless vertebrates use variable lymphocyte receptors (VLR) comprised of leucine-rich-repeat (LRR) segments as counterparts of… Expand
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Review
2008
Review
2008
Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals. It occurs by a… Expand
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Highly Cited
2008
Highly Cited
2008
The transcription factors Foxo1, Foxo3 and Foxo4 modulate cell fate 'decisions' in diverse systems. Here we show that Foxo1… Expand
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Highly Cited
2005
Highly Cited
2005
IL-21 is a type I cytokine that influences the function of T cells, NK cells, and B cells. In this study, we report that IL-21… Expand
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Highly Cited
2004
Highly Cited
2004
A feature of Ig hypermutation is the presence of hypermutable DNA sequences that are preferentially found in the V regions of Ig… Expand
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Highly Cited
2003
Highly Cited
2003
Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided a comprehensive picture of immune… Expand
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