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Activation-Induced Cytidine Deaminase

Known as: Cytidine Aminohydrolase, EC 3.5.4.5 
Activation-induced cytidine deaminase (198 aa, ~24 kDa) is encoded by the human AICDA gene. This protein plays a role in both B-cell functioning and… Expand
National Institutes of Health

Related topics

Related topics

7 relations
AICDA geneDNA Methylation RegulationEnzyme GeneHydrolysis
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The cell cycle restricts activation-induced cytidine deaminase activity to early G1
Activation-induced cytidine deaminase (AID) converts cytosine into uracil to initiate somatic hypermutation (SHM) and class… Expand
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Review
2011
Review
2011
Complex regulation and function of activation-induced cytidine deaminase.
Activation-induced cytidine deaminase (AID) instigates mutations and DNA breaks in Ig genes that undergo somatic hypermutation… Expand
Is this relevant?
Review
2009
Review
2009
Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G.
Activation-induced cytidine deaminase (AID) and APOBEC3G catalyze deamination of cytosine to uracil on single-stranded DNA… Expand
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2008
2008
Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination in B cells by… Expand
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Highly Cited
2007
Highly Cited
2007
Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.
Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression… Expand
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2006
2006
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.
Activation-induced cytidine deaminase (AID) is a single-stranded DNA deaminase required for somatic hypermutation of… Expand
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2006
2006
Identification of a specific domain required for dimerization of activation-induced cytidine deaminase.
Activation-induced cytidine deaminase (AID) is essential to all three genetic alterations required for generation of antigen… Expand
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Highly Cited
2004
Highly Cited
2004
Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency.
Mutations of the Activation-Induced Cytidine Deaminase (AID) gene have been found in patients with autosomal recessive hyper-IgM… Expand
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