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AFF3 gene

Known as: AFF3, AF4/FMR2 family member 3, AF4/FMR2 FAMILY, MEMBER 3 
This gene is involved in transcriptional activation and is purported to play roles in lymphoid development and oncogenesis.
National Institutes of Health

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AFF3 wt Allele
Homo sapiensLAF4 protein, humanTranscriptional ActivationTranscriptional Regulation

Papers overview

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Highly Cited
2018
Highly Cited
2018
Genome-wide identification of transcription factors that are critical to non-small cell lung cancer.
2017
2017
Genetics of Diabetic Kidney Disease-From the Worst of Nightmares to the Light of Dawn?
Despite improved clinical care in patients with diabetes, diabetic complications remain a major healthcare burden. The management… 
2016
2016
A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron
Abstract Genomic imprinting is an epigenetic regulation that leads to gene expression in a parent-of-origin specific manner. AFF3… 
Highly Cited
2014
Highly Cited
2014
Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4
Developing anti-viral therapies targeting HIV-1 transcription has been hampered by the limited structural knowledge of the… 
2014
2014
FRA2A Is a CGG Repeat Expansion Associated with Silencing of AFF3
Folate-sensitive fragile sites (FSFS) are a rare cytogenetically visible subset of dynamic mutations. Of the eight molecularly… 
2013
2013
Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis.
OBJECTIVE Heritability studies have suggested an important role of genetic predisposition in the progression of joint destruction… 
Highly Cited
2012
Highly Cited
2012
Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients
Introduction There are now over 30 confirmed loci predisposing to rheumatoid arthritis (RA). Studies have been largely undertaken… 
Highly Cited
2011
Highly Cited
2011
Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci.
OBJECTIVE To perform a genome-wide association study (GWAS) in Koreans in order to identify susceptibility loci for rheumatoid… 
2008
2008
Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA
The AML1 gene is frequently rearranged by chromosomal translocations in acute leukemia. We identified that the LAF4 gene on 2q11… 
2003
2003
Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)
We showed that the LAF4 gene on 2q11.2–12 was fused to the MLL gene on 11q23 in a pediatric patient with CD10 positive acute… 
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