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IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report.
TLDR
IKZF1 deletions are likely to be a genomic alteration that significantly affects the prognosis of Ph-positive ALL in adults, andMultivariate analysis confirmed the negative prognostic impact of IKzF1 deletion on DFS. Expand
Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of
TLDR
Known DNA sequences and structural features were mapped along the breakpoint cluster regions, including heptamer recombination signal sequences recognized by RAG enzymes during V(D)J recombination, suggesting that IKZF1 deletions could arise from aberrant RAG-mediated recombination. Expand
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.
TLDR
It is shown that a t(7;16)(q33;p11) in two cases of low grade fibromyxoid sarcoma fuses the FUS gene to BBF2H7, a previously uncharacterized gene that is homologous to the Drosophila Bbf-2 gene. Expand
The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells.
TLDR
Observations strongly suggest that CCR8 plays a role in the control of Th2 responses, and may represent a potential target for treatment of allergic diseases. Expand
IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic Leukemia
TLDR
It is found that Ikaros deleted isoforms lacked the ability to directly regulate a large group of the genes in the signature, such as IGLL1, BLK, EBF1, MSH2, BUB3, ETV6, YES1, CDKN1A (p21), CDKN2C (p18) and MCL1. Expand
Pre–B cell receptor–mediated cell cycle arrest in Philadelphia chromosome–positive acute lymphoblastic leukemia requires IKAROS function
TLDR
It is demonstrated that the pre–B cell receptor functions as a tumor suppressor upstream of IKAROS through induction of cell cycle arrest in Ph+ ALL cells, and IKarOS-mediated cell cycle exit is identified as the endpoint of an emerging pathway of pre– B cell receptor–mediated tumor suppression. Expand
Breakpoint characterization of der(9) deletions in chronic myeloid leukemia patients
TLDR
A minimally deleted region on both chromosomes 9 and 22 was identified and was found to contain the ASS gene on chromosome 9 and IGLL1 on chromosome 22. Expand
Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies.
TLDR
The results exclude MYC as the target gene and indicate that overexpression of C8FW may be the functionally important consequence of 8q24 amplicons in AML and MDS. Expand
Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure.
TLDR
This paper investigates 10 cell lines from solid tumors showing MYCN amplification as dmin or hsr, and strongly argues that the episome model applies to solid tumors as well, and that dmin and hsr are two faces of the same coin. Expand
CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia
TLDR
Two chimeric transcripts identified in AML translocation cases involving CBFA2T2 (core-binding factor, runt domain, α subunit; translocated to, 2), an ETO homologous gene on chromosome 20, and C20orf112 are characterized. Expand
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