Skip to search formSkip to main contentSkip to account menu

AF 353

Known as: AF-353, AF353 cpd 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Electroacupuncture Alleviates Bladder Overactivity via Inhabiting Bladder P2X3 Receptor
Electroacupuncture (EA) has been widely applied for overactive bladder, but the mechanism of its action remains to be clarified… 
Highly Cited
2018
Highly Cited
2018
Druggable negative allosteric site of P2X3 receptors
  • Jin WangYao Wang Ye Yu
  • Proceedings of the National Academy of Sciences
  • 2018
  • Corpus ID: 4981140
Significance Allosteric regulation, produced by the binding of a ligand at an allosteric site topographically distinct from the… 
2018
2018
Modulatory effects of intravesical P2X2/3 purinergic receptor inhibition on lower urinary tract electromyographic properties and voiding function of female rats with moderate or severe spinal cord…
To evaluate the role that intravesical P2X2/3 purinergic receptors (P2X2/3Rs) play in early and advanced neurogenic lower urinary… 
Highly Cited
2015
Highly Cited
2015
Postsynaptic P2X3‐containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice
Acute inhibition of purinergic receptors with a selective P2X3 antagonist prevents transmission of information from taste buds to… 
2014
2014
MP17-13 FUNCTIONAL-MRI DURING BLADDER CYSTOMETRY IN SPINAL CORD-INJURED AND INTACT FEMALE RATS
2012
2012
A role for ATP in bronchoconstriction‐induced activation of guinea pig vagal intrapulmonary C‐fibres
•  Activation of bronchopulmonary C‐fibres can lead to parasympathetic reflex bronchoconstriction, mucus secretion, as well as… 
2012
2012
Modulation of bladder afferent signals in normal and spinal cord‐injured rats by purinergic P2X3 and P2X2/3 receptors
What's known on the subject? and What does the study add? 
Highly Cited
2010
Highly Cited
2010
AF‐353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
Background and purpose:  Purinoceptors containing the P2X3 subunit (P2X3 homotrimeric and P2X2/3 heterotrimeric) are members of… 
Highly Cited
2010
Highly Cited
2010
Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats.
Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases… 
2010
2010
Systemic blockade of P 2 X 3 and P 2 X 2 / 3 receptors attenuates bone cancer pain behaviour in rats
Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)