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AF 353

Known as: AF-353, AF353 cpd 
National Institutes of Health

Papers overview

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2018
2018
Modulatory effects of intravesical P2X2/3 purinergic receptor inhibition on lower urinary tract electromyographic properties and voiding function of female rats with moderate or severe spinal cord…
To evaluate the role that intravesical P2X2/3 purinergic receptors (P2X2/3Rs) play in early and advanced neurogenic lower urinary… 
2016
2016
Central role for the TRPV4-ATP-P2X3 axis in sensory nerve activation and the late asthmatic response
The late asthmatic response (LAR) is a defining symptom of asthma and is regularly used as a model for proof of concept clinical… 
2016
2016
Hypertension: Purinergic receptor inhibition lowers blood pressure
trolled by existing therapies owing, in part, to resistance to antihypertensive medications, poor compliance and side effects… 
2014
2014
MP17-13 FUNCTIONAL-MRI DURING BLADDER CYSTOMETRY IN SPINAL CORD-INJURED AND INTACT FEMALE RATS
2014
2014
MP17-12 EFFECTS OF UROTHELIAL P2X3 RECEPTOR INHIBITION ON RAT BLADDER CONTRACTILITY
2014
2014
MP17-14 CORRECTION OF HYPERGLYCEMIA AND HYPERINSULINEMIA BY GENETIC MODIFICATION RESTORES BLADDER DYSFUNCTION ASSOCIATED WITH TYPE 2 DIABETES
2011
2011
211 EFFECTS OF GLYCINE TRANSPORTER INHIBITORS ON BLADDER OVERACTIVITY IN RATS WITH CYCLOPHOSPHAMIDE-INDUCED CYSTITIS
2010
2010
Systemic blockade of P 2 X 3 and P 2 X 2 / 3 receptors attenuates bone cancer pain behaviour in rats
Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases… 
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