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AF 353

Known as: AF-353, AF353 cpd 
 
National Institutes of Health

Papers overview

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2019
2019
Modulatory effects of intravesical P2X2/3 purinergic receptor inhibition on lower urinary tract electromyographic properties and voiding function of female rats with moderate or severe spinal cord…
OBJECTIVES To evaluate the role that intravesical P2X2/3 purinergic receptors (P2X2/3Rs) play in early and advanced neurogenic… Expand
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2018
2018
Druggable negative allosteric site of P2X3 receptors
  • Jin Wang, Yao Wang, +11 authors Ye Yu
  • Proceedings of the National Academy of Sciences
  • 2018
    • Corpus ID: 4981140
Significance Allosteric regulation, produced by the binding of a ligand at an allosteric site topographically distinct from the… Expand
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2016
2016
Central role for the TRPV4-ATP-P2X3 axis in sensory nerve activation and the late asthmatic response
The late asthmatic response (LAR) is a defining symptom of asthma and is regularly used as a model for proof of concept clinical… Expand
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2015
2015
Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice.
Taste buds release ATP to activate ionotropic purinoceptors composed of P2X2 and P2X3 subunits, present on the taste nerves. Mice… Expand
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2015
2015
TRPV4 and activation of airway sensory nerves: The role of ATP
Activation of TRPV4 causes vagal nerve depolarisation, single airway fibre firing and reflex cough in the guinea pig (GP) through… Expand
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2012
2012
A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres.
Activation of vagal afferent sensory C-fibres in the lungs leads to reflex responses that produce many of the symptoms associated… Expand
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2012
2012
Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3 receptors.
OBJECTIVE To evaluate the role of bladder sensory purinergic P2X3 and P2X2/3 receptors on modulating the activity of lumbosacral… Expand
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Highly Cited
2010
Highly Cited
2010
AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.
BACKGROUND AND PURPOSE Purinoceptors containing the P2X3 subunit (P2X3 homotrimeric and P2X2/3 heterotrimeric) are members of the… Expand
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Highly Cited
2010
Highly Cited
2010
Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats.
Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases… Expand
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2010
2010
Systemic blockade of P 2 X 3 and P 2 X 2 / 3 receptors attenuates bone cancer pain behaviour in rats
Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases… Expand
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