AF 353

To evaluate the role that intravesical P2X2/3 purinergic receptors (P2X2/3Rs) play in early and advanced neurogenic lower urinary… Expand

Significance Allosteric regulation, produced by the binding of a ligand at an allosteric site topographically distinct from the… Expand

The late asthmatic response (LAR) is a defining symptom of asthma and is regularly used as a model for proof of concept clinical… Expand

Acute inhibition of purinergic receptors with a selective P2X3 antagonist prevents transmission of information from taste buds to… Expand

Activation of TRPV4 causes vagal nerve depolarisation, single airway fibre firing and reflex cough in the guinea pig (GP) through… Expand

•  Activation of bronchopulmonary C‐fibres can lead to parasympathetic reflex bronchoconstriction, mucus secretion, as well as… Expand

What's known on the subject? and What does the study add? 

Background and purpose:  Purinoceptors containing the P2X3 subunit (P2X3 homotrimeric and P2X2/3 heterotrimeric) are members of… Expand

Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases… Expand

Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases… Expand