AF 353

Allosteric modulation provides exciting opportunities for drug discovery of enzymes, ion channels, and G protein-coupled… (More)

trolled by existing therapies owing, in part, to resistance to antihypertensive medications, poor compliance and side effects… (More)

Taste buds release ATP to activate ionotropic purinoceptors composed of P2X2 and P2X3 subunits, present on the taste nerves. Mice… (More)

OBJECTIVE To evaluate the role of bladder sensory purinergic P2X3 and P2X2/3 receptors on modulating the activity of lumbosacral… (More)

Activation of vagal afferent sensory C-fibres in the lungs leads to reflex responses that produce many of the symptoms associated… (More)

BACKGROUND AND PURPOSE Purinoceptors containing the P2X3 subunit (P2X3 homotrimeric and P2X2/3 heterotrimeric) are members of the… (More)

Pain remains an area of considerable unmet clinical need, and this is particularly true of pain associated with bone metastases… (More)