Chondroitinase ABC promotes functional recovery after spinal cord injury
It is demonstrated that CSPGs are important inhibitory molecules in vivo and suggested that their manipulation will be useful for treatment of human spinal injuries.
Tackling Pain at the Source: New Ideas about Nociceptors
Neurotrophins: mediators and modulators of pain.
The chapter reviews the evidence for these roles (and briefly the effects of other neurotrophins), the range of conditions under which they act, and their mechanism of action.
Immunocytochemical Localization of trkA Receptors in Chemically Identified Subgroups of Adult Rat Sensory Neurons
- S. Averill, S. McMahon, D. Clary, L. Reichardt, J. Priestley
- BiologyEuropean Journal of Neuroscience
- 1 July 1995
Results show that trkA‐expressing cells in dorsal root ganglia correspond almost exactly with the CGRP, peptide‐producing population, and the receptor is present not only on cell bodies but also on central terminals.
Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve Injury
GDNF can prevent several axotomy-induced changes in neurons, including the downregulation of IB4 binding, TMP activity, and somatostatin expression and may protect peripheral neurons that are refractory to neurotrophin treatment.
Role of the Immune system in chronic pain
This work has shown that immune cell products might have a crucial role not just in inflammatory pain, but also in neuropathic pain caused by damage to peripheral nerves or to the CNS.
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X 3-deficient mice
P2X3 is critical for peripheral pain responses and afferent pathways controlling urinary bladder volume reflexes and may have therapeutic potential in the treatment of disorders of urine storage and voiding such as overactive bladder.
Potent analgesic effects of GDNF in neuropathic pain states.
It is demonstrated that glial cell line-derived neurotrophic factor (GDNF) both prevented and reversed sensory abnormalities that developed in neuropathic pain models, without affecting pain-related behavior in normal animals.
The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor.
Glial cell line-derived neurotrophic factor (GDNF), delivered intrathecally, completely reversed axotomy-induced down-regulation of the P2X3 receptor and it is concluded that P2x3 receptors are normally expressed in nociceptive primary sensory neurons, predominantly the nonpeptidergic nocICEptors.