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- Publications
- Influence
Chondroitinase ABC promotes functional recovery after spinal cord injury
- E. Bradbury, L. Moon, +5 authors S. McMahon
- Biology, Medicine
- Nature
- 11 April 2002
The inability of axons to regenerate after a spinal cord injury in the adult mammalian central nervous system (CNS) can lead to permanent paralysis. At sites of CNS injury, a glial scar develops,… Expand
Tackling Pain at the Source: New Ideas about Nociceptors
- W. Snider, S. McMahon
- Medicine
- Neuron
- 1 April 1998
In this minireview, we have discussed new data highlighting the distinct properties of subsets of nociceptors that in turn raise questions regarding their functional roles. The concept of two major… Expand
Neurotrophins: mediators and modulators of pain.
- S. Pezet, S. McMahon
- Psychology, Medicine
- Annual review of neuroscience
- 15 June 2006
The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal survival and growth. Over the past decade, considerable evidence has accumulated from both humans and… Expand
Immunocytochemical Localization of trkA Receptors in Chemically Identified Subgroups of Adult Rat Sensory Neurons
- S. Averill, S. McMahon, D. Clary, L. Reichardt, J. Priestley
- Biology, Medicine
- The European journal of neuroscience
- 1 July 1995
Immunocytochemistry has been used to examine the location of trkA, the high‐affinity receptor for nerve growth factor, in adult rat dorsal root ganglia, trigeminal ganglia and spinal cord. TrkA… Expand
Role of the Immune system in chronic pain
- F. Marchand, M. Perretti, S. McMahon
- Medicine
- Nature Reviews Neuroscience
- 1 July 2005
During the past two decades, an important focus of pain research has been the study of chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity — spontaneous pain and… Expand
A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve Injury
- D. Bennett, G. J. Michael, +5 authors J. Priestley
- Biology, Medicine
- The Journal of Neuroscience
- 15 April 1998
Several lines of evidence suggest that neurotrophin administration may be of some therapeutic benefit in the treatment of peripheral neuropathy. However, a third of sensory neurons do not express… Expand
The Expression of P2X3Purinoreceptors in Sensory Neurons: Effects of Axotomy and Glial-Derived Neurotrophic Factor
- E. Bradbury, G. Burnstock, S. McMahon
- Biology
- Molecular and Cellular Neuroscience
- 1 November 1998
We have studied the distribution and regulation of the P2X3 receptor (a ligand-gated ion channel activated by ATP) in adult dorsal root ganglion (DRG) neurons using a polyclonal antibody. P2X3… Expand
Potent analgesic effects of GDNF in neuropathic pain states.
- T. J. Boucher, K. Okuse, D. Bennett, J. Munson, J. Wood, S. McMahon
- Medicine
- Science
- 6 October 2000
Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here that glial… Expand
The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor.
- E. Bradbury, G. Burnstock, S. McMahon
- Medicine
- Molecular and cellular neurosciences
- 1998
We have studied the distribution and regulation of the P2X3 receptor (a ligand-gated ion channel activated by ATP) in adult dorsal root ganglion (DRG) neurons using a polyclonal antibody. P2X3… Expand
Chondroitinase ABC Promotes Sprouting of Intact and Injured Spinal Systems after Spinal Cord Injury
- A. Barritt, M. Davies, +5 authors E. Bradbury
- Biology, Medicine
- The Journal of Neuroscience
- 18 October 2006
Chondroitin sulfate proteoglycans (CSPGs) are inhibitory extracellular matrix molecules that are upregulated after CNS injury. Degradation of CSPGs using the enzyme chondroitinase ABC (ChABC) can… Expand