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Tackling Pain at the Source: New Ideas about Nociceptors
TLDR
This minireview has discussed new data highlighting the distinct properties of subsets of nociceptors that in turn raise questions regarding their functional roles, and suggested that GDNF or related molecules may also offer an important target in the development of novel analgesic therapies.
Chondroitinase ABC promotes functional recovery after spinal cord injury
TLDR
It is demonstrated that CSPGs are important inhibitory molecules in vivo and suggested that their manipulation will be useful for treatment of human spinal injuries.
Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
TLDR
Examination of the central nervous system revealed that, in marked contrast with neurons of sensory and sympathetic ganglia, basal forebrain cholinergic neurons differentiate and continue to express phenotypic markers for the life span of the null mutant mice, suggesting differentiation and initial survival of central NGF-responsive neurons can occur in the absence of NGF.
Immunocytochemical Localization of trkA Receptors in Chemically Identified Subgroups of Adult Rat Sensory Neurons
TLDR
Results show that trkA‐expressing cells in dorsal root ganglia correspond almost exactly with the CGRP, peptide‐producing population, and the receptor is present not only on cell bodies but also on central terminals.
Neurotrophins: mediators and modulators of pain.
TLDR
The chapter reviews the evidence for these roles (and briefly the effects of other neurotrophins), the range of conditions under which they act, and their mechanism of action.
A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve Injury
TLDR
GDNF can prevent several axotomy-induced changes in neurons, including the downregulation of IB4 binding, TMP activity, and somatostatin expression and may protect peripheral neurons that are refractory to neurotrophin treatment.
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X 3-deficient mice
TLDR
P2X3 is critical for peripheral pain responses and afferent pathways controlling urinary bladder volume reflexes and may have therapeutic potential in the treatment of disorders of urine storage and voiding such as overactive bladder.
Role of the Immune system in chronic pain
TLDR
This work has shown that immune cell products might have a crucial role not just in inflammatory pain, but also in neuropathic pain caused by damage to peripheral nerves or to the CNS.
The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor.
TLDR
Glial cell line-derived neurotrophic factor (GDNF), delivered intrathecally, completely reversed axotomy-induced down-regulation of the P2X3 receptor and it is concluded that P2x3 receptors are normally expressed in nociceptive primary sensory neurons, predominantly the nonpeptidergic nocICEptors.
The Expression of P2X3Purinoreceptors in Sensory Neurons: Effects of Axotomy and Glial-Derived Neurotrophic Factor
TLDR
Glial cell line-derived neurotrophic factor (GDNF), delivered intrathecally, completely reversed axotomy-induced down-regulation of the P2X3 receptor and it is concluded that P2x3 receptors are normally expressed in nociceptive primary sensory neurons, predominantly the nonpeptidergic nocICEptors.
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