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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletalExpand
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Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.
Peroxisome proliferator activator receptor-gamma coactivator 1 (PGC-1) is a major candidate gene for diabetes-related metabolic phenotypes, contributing to decreased expression of nuclear-encodedExpand
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Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
Alternative mRNA splicing provides transcript diversity and may contribute to human disease. We demonstrate that expression of several genes regulating RNA processing is decreased in both liver andExpand
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Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress
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Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator‐activated receptor‐γ coactivator‐1α and ‐1β in cultured myotubes
The peroxisome proliferator‐activated receptor γ coactivator‐1 (PGC‐1) family is a key regulator of mitochondrial function, and reduced mRNA expression may contribute to muscle lipid accumulation inExpand
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Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.
The study was designed to evaluate whether changes in malonyl-CoA and the enzymes that govern its concentration occur in human muscle as a result of physical training. Healthy, middle-aged subjectsExpand
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Links between thyroid hormone action, oxidative metabolism, and diabetes risk?
A key phenotype associated with type 2 diabetes in humans is impaired mitochondrial oxidative metabolism in skeletal muscle, a pattern potentially contributing to increased lipid accumulation andExpand
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Trial watch: PCSK9 antibody reduces LDL cholesterol
Preliminary Phase II trial results for REGN727 — a human proprotein convertase subtilisin/kexin type 9 (PCSK9)-specific monoclonal antibody co-developed by Regeneron and Sanofi — indicate that itExpand
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Anticancer drugs: Redesigning kinase inhibitors
highly successful in the treatment of both chronic myelogenous leukaemia (CML) and gastrointestinal stromal tumours (GISTs); however, it has been associated with uncommon, but severe, cardiotoxicity.Expand
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Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue.
To identify novel pathways mediating molecular mechanisms of thiazolidinediones (TZDs) in humans, we assessed gene expression in adipose and muscle tissue from six subjects with type 2 diabetesExpand
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