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ADGRG1 gene

Known as: Adhesion G Protein-Coupled Receptor G1 Gene, 7-TRANSMEMBRANE PROTEIN WITH NO EGF-LIKE N-TERMINAL DOMAINS 1, GPR56 
This gene is involved in both brain development and signaling.
National Institutes of Health

Related topics

Related topics

7 relations
Cell-Cell Adhesion ProcessG Protein-Coupled Receptor SignalingIntercellular Communication ProcessLigand Binding

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GPR56 wt Allele

Papers overview

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Highly Cited
2017
Highly Cited
2017
Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region
Significance G protein-coupled receptors enable cells to sense extracellular signals and translate them into physiological… 
Highly Cited
2016
Highly Cited
2016
Adhesion G Protein-Coupled Receptor G1 (ADGRG1/GPR56) and Pancreatic β-Cell Function.
CONTEXT Adhesion G protein-coupled receptor (GPCR)-G1 (ADGRG1) is the most abundant GPCR in human pancreatic islets, but its role… 
2016
2016
Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility
ABSTRACT GPR56 is an adhesion-class G-protein-coupled receptor responsible for bilateral frontoparietal polymicrogyria (BFPP), a… 
Highly Cited
2015
Highly Cited
2015
Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)*
The adhesion G protein-coupled receptors (aGPCRs) are a large yet poorly understood family of seven-transmembrane proteins. A… 
2015
2015
The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration.
Highly Cited
2014
Highly Cited
2014
The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA
In the vertebrate central nervous system, myelinating oligodendrocytes are postmitotic and derive from proliferative… 
2009
2009
Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis
PurposeGPR56 is an orphan G-protein-coupled receptor of the adhesion family involved in brain development. In some cancer cells… 
Highly Cited
2007
Highly Cited
2007
Disease-associated mutations affect GPR56 protein trafficking and cell surface expression.
Bilateral frontoparietal polymicrogyria (BFPP) is a congenital brain malformation resulting in irregularities on the surface of… 
Highly Cited
2003
Highly Cited
2003
There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.
Highly Cited
1999
Highly Cited
1999
GPR56, a novel secretin-like human G-protein-coupled receptor gene.
A novel gene product, GPR56, with homology to the seven transmembrane-domain receptor superfamily, has been cloned by PCR… 
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