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ADAMTS13 protein, human

Known as: ADAMTS-13, A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13, VWFCP protein, human 
A disintegrin and metalloproteinase with thrombospondin motifs 13 (1427 aa, ~154 kDa) is encoded by the human ADAMTS13 gene. This protein plays a… 
National Institutes of Health

Related topics

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16 relations

Broader (1)

ADAMTS13 Protein
ADAMTS13 geneBlood coagulationDisintegrin DomainEnzyme Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics
Thrombotic thrombocytopenic purpura (TTP), a potentially fatal clinical syndrome, is primarily caused by autoantibodies against… 
Highly Cited
2015
Highly Cited
2015
Cardiac troponin‐I on diagnosis predicts early death and refractoriness in acquired thrombotic thrombocytopenic purpura. Experience of the French Thrombotic Microangiopathies Reference Center
Cardiac involvement is a major cause of mortality in patients with thrombotic thrombocytopenic purpura (TTP). However, diagnosis… 
Highly Cited
2009
Highly Cited
2009
Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: A mechanism associated with sickle cell disease
Summary Vascular occlusion, thromboembolism and strokes are hallmark events in sickle cell disease (SCD). The von Willebrand… 
Review
2005
Review
2005
Cleavage of ultra‐large von Willebrand factor by ADAMTS‐13 under flow conditions
Summary.  von Willebrand factor (VWF) is a critical ligand for platelet adhesion and aggregation. It is synthesized and released… 
Highly Cited
2005
Highly Cited
2005
Cysteine‐mutations in von Willebrand factor associated with increased clearance
Summary.  Background: von Willebrand disease (VWD) is a bleeding disorder caused by the decrease of functional von Willebrand… 
Highly Cited
2005
Highly Cited
2005
Platelet‐derived VWF‐cleaving metalloprotease ADAMTS‐13
Summary.  The adhesion ligand von Willebrand factor (VWF) is synthesized and stored in vascular endothelial cells and… 
Review
2004
Review
2004
Measurement of von Willebrand factor cleaving protease (ADAMTS‐13): results of an international collaborative study involving 11 methods testing the same set of coded plasmas
Summary.  Background: ADAMTS‐13 is a von Willebrand factor (VFW)‐cleaving protease. Its congenital or acquired deficiency is… 
Highly Cited
2003
Highly Cited
2003
Nonneutralizing IgM and IgG antibodies to von Willebrand factor-cleaving protease (ADAMTS-13) in a patient with thrombotic thrombocytopenic purpura.
Acquired thrombotic thrombocytopenic purpura (TTP) has been linked to severe deficiency of ADAMTS-13 activity caused by… 
Highly Cited
2003
Highly Cited
2003
ADAMTS-13 Metalloprotease Interacts with the Endothelial Cell-derived Ultra-large von Willebrand Factor*
Thrombotic thrombocytopenic purpura is caused by congenital or acquired deficiency of ADAMTS-13, a metalloprotease that cleaves… 
Highly Cited
2003
Highly Cited
2003
Von Willebrand factor cleaving protease (ADAMTS-13) in 123 patients with connective tissue diseases (systemic lupus erythematosus and systemic sclerosis).
BACKGROUND AND OBJECTIVES Autoantibodies inactivating the von Willebrand factor (VWF) cleaving protease, ADAMTS-13, are among the… 
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