ADAMTS13 Protein

Known as: ADAMTS-13 Protein, A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein, ADAMTS13 Protease 
An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
051019972017

Papers overview

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Highly Cited
2009
Highly Cited
2009
Stroke is a leading cause of death and disability. The only therapy available is recombinant tissue plasminogen activator, but… (More)
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2008
2008
BACKGROUND Thrombocytopenia-associated multiple organ failure (TAMOF) is a poorly understood syndrome in critically ill children… (More)
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2003
2003
Genetic analysis of the ADAMTS13 locus identified six mutations in the ADAMTS13 genes of two brothers suffering from… (More)
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Highly Cited
2002
Highly Cited
2002
A severe deficiency in von Willebrand factor-cleaving protease (ADAMTS13) activity (< 5% that in normal plasma) has been observed… (More)
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Highly Cited
2001
Highly Cited
2001
Thrombotic thrombocytopenic purpura is associated with acquired or congenital deficiency of a plasma von Willebrand factor… (More)
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Highly Cited
2001
Highly Cited
2001
von Willebrand factor-cleaving protease (vWF-cp) is responsible for the continuous degradation of plasma vWF multimers released… (More)
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Highly Cited
2001
Highly Cited
2001
Retrospective studies of patients with thrombotic microangiopathies (TMAs) have shown that a deficient activity of von Willebrand… (More)
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Highly Cited
1999
Highly Cited
1999
Patients with thrombotic thrombocytopenic purpura (TTP) have a deficiency of von Willebrand factor (vWF)-cleaving protease… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Thrombotic thrombocytopenic purpura is a potentially fatal disease characterized by widespread platelet thrombi in the… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome are severe microvascular disorders of platelet… (More)
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