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ACTN4 wt Allele

Known as: Actinin, Alpha-4 Gene, Focal Segmental Glomerulosclerosis 1 Gene, ACTININ-4 
Human ACTN4 wild-type allele is located in the vicinity of 19q13 and is approximately 84 kb in length. This allele, which encodes alpha-actinin-4… Expand
National Institutes of Health

Related topics

Related topics

7 relations
19q13ACTN4 geneCalcium BindingCytoskeletal Modeling
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction
α-Actinin-4 plays an important role in coupling actin nucleation to assembly at cadherin-based cell–cell adhesive contacts. 
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Highly Cited
2010
Highly Cited
2010
Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4
In addition to its well-known role as a crosslinker of actin filaments at focal-adhesion sites, actinin-4 is known to be… Expand
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Highly Cited
2009
Highly Cited
2009
Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance
Actinin-4, an isoform of non-muscular α-actinin, enhances cell motility by bundling the actin cytoskeleton. We previously… Expand
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Highly Cited
2008
Highly Cited
2008
Expression and Gene Amplification of Actinin-4 in Invasive Ductal Carcinoma of the Pancreas
Purpose: An invasive growth pattern is one of the hallmarks of pancreatic ductal carcinoma. Actinin-4 is an actin-binding protein… Expand
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Highly Cited
2007
Highly Cited
2007
Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type
Actinin-4 is an isoform of non-muscular α-actinin and actin-bundling protein. By enhancing cell motility, actinin-4 shows… Expand
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Highly Cited
2005
Highly Cited
2005
Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.
BACKGROUND & AIMS Enhanced motility of cancer cells by remodeling of the actin cytoskeleton seems crucial in the process of… Expand
Highly Cited
2003
Highly Cited
2003
Statin therapy in patients with coronary artery disease improves the impaired endothelial progenitor cell differentiation into cardiomyogenic cells
Abstract.Human endothelial progenitor cells (EPCs) can differentiate into cardiomyogenic cells in vitro. We tested the effects of… Expand
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Highly Cited
2001
Highly Cited
2001
CD2AP and p130Cas localize to different F-actin structures in podocytes.
Mice lacking the 80-kDa CD2-associated protein (CD2AP) develop progressive renal failure that starts soon after birth with… Expand
Highly Cited
2000
Highly Cited
2000
Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging.
We have applied fluorescence ratio imaging to the analysis of an actin-binding protein concentration relative to F-actin in… Expand
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Highly Cited
1998
Highly Cited
1998
Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion
Regulation of the actin cytoskeleton may play a crucial role in cell motility and cancer invasion. We have produced a monoclonal… Expand
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