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ACTN4 wt Allele
Known as:
Actinin, Alpha-4 Gene
, Focal Segmental Glomerulosclerosis 1 Gene
, ACTININ-4
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Human ACTN4 wild-type allele is located in the vicinity of 19q13 and is approximately 84 kb in length. This allele, which encodes alpha-actinin-4…
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National Institutes of Health
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Related topics
Related topics
7 relations
19q13
ACTN4 gene
Calcium Binding
Cytoskeletal Modeling
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction
Vivian W. Tang
,
W. Brieher
The Journal of cell biology
2012
Corpus ID: 346968
α-Actinin-4 plays an important role in coupling actin nucleation to assembly at cadherin-based cell–cell adhesive contacts.
Highly Cited
2010
Highly Cited
2010
Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4
M. Kumeta
,
S. Yoshimura
,
M. Harata
,
K. Takeyasu
Journal of Cell Science
2010
Corpus ID: 19412834
In addition to its well-known role as a crosslinker of actin filaments at focal-adhesion sites, actinin-4 is known to be…
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Highly Cited
2009
Highly Cited
2009
Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance
S. Yamamoto
,
H. Tsuda
,
+7 authors
O. Matsubara
Modern Pathology
2009
Corpus ID: 13071586
Actinin-4, an isoform of non-muscular α-actinin, enhances cell motility by bundling the actin cytoskeleton. We previously…
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Highly Cited
2008
Highly Cited
2008
Expression and Gene Amplification of Actinin-4 in Invasive Ductal Carcinoma of the Pancreas
S. Kikuchi
,
K. Honda
,
+13 authors
T. Yamada
Clinical Cancer Research
2008
Corpus ID: 1251716
Purpose: An invasive growth pattern is one of the hallmarks of pancreatic ductal carcinoma. Actinin-4 is an actin-binding protein…
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Highly Cited
2007
Highly Cited
2007
Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type
S. Yamamoto
,
H. Tsuda
,
+6 authors
O. Matsubara
Modern Pathology
2007
Corpus ID: 33774323
Actinin-4 is an isoform of non-muscular α-actinin and actin-bundling protein. By enhancing cell motility, actinin-4 shows…
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Highly Cited
2005
Highly Cited
2005
Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.
K. Honda
,
T. Yamada
,
+6 authors
S. Hirohashi
Gastroenterology
2005
Corpus ID: 8918894
BACKGROUND & AIMS Enhanced motility of cancer cells by remodeling of the actin cytoskeleton seems crucial in the process of…
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Highly Cited
2003
Highly Cited
2003
Statin therapy in patients with coronary artery disease improves the impaired endothelial progenitor cell differentiation into cardiomyogenic cells
Stefan Rupp
,
C. Badorff
,
+5 authors
S. Dimmeler
Basic Research in Cardiology
2003
Corpus ID: 19834537
Abstract.Human endothelial progenitor cells (EPCs) can differentiate into cardiomyogenic cells in vitro. We tested the effects of…
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Highly Cited
2001
Highly Cited
2001
CD2AP and p130Cas localize to different F-actin structures in podocytes.
T. Welsch
,
N. Endlich
,
W. Kriz
,
K. Endlich
American journal of physiology. Renal physiology
2001
Corpus ID: 24706759
Mice lacking the 80-kDa CD2-associated protein (CD2AP) develop progressive renal failure that starts soon after birth with…
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Highly Cited
2000
Highly Cited
2000
Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging.
N. Araki
,
T. Hatae
,
T. Yamada
,
S. Hirohashi
Journal of cell science
2000
Corpus ID: 20017225
We have applied fluorescence ratio imaging to the analysis of an actin-binding protein concentration relative to F-actin in…
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Highly Cited
1998
Highly Cited
1998
Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion
Kazufumi Honda
,
T. Yamada
,
+6 authors
S. Hirohashi
The Journal of cell biology
1998
Corpus ID: 6821332
Regulation of the actin cytoskeleton may play a crucial role in cell motility and cancer invasion. We have produced a monoclonal…
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