ACTN4 wt Allele

Known as: Actinin, Alpha-4 Gene, Focal Segmental Glomerulosclerosis 1 Gene, ACTININ-4 
Human ACTN4 wild-type allele is located in the vicinity of 19q13 and is approximately 84 kb in length. This allele, which encodes alpha-actinin-4… (More)
National Institutes of Health

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19q13ACTN4 geneCalcium BindingCytoskeletal Modeling
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Papers overview

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2013
2013
Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions.
During wound repair, epidermal cells at the edge of an injury establish front-rear polarity through orchestrated changes in their… (More)
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Highly Cited
2012
Highly Cited
2012
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction
We have developed an in vitro assay to study actin assembly at cadherin-enriched cell junctions. Using this assay, we demonstrate… (More)
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2009
2009
Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinoma.
OBJECTIVES Actinin-4 is an actin-bundling protein that probably has a tumor-promoting potential in several solid tumors. The… (More)
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Highly Cited
2008
Highly Cited
2008
Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas.
PURPOSE An invasive growth pattern is one of the hallmarks of pancreatic ductal carcinoma. Actinin-4 is an actin-binding protein… (More)
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2007
2007
Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type
Actinin-4 is an isoform of non-muscular α-actinin and actin-bundling protein. By enhancing cell motility, actinin-4 shows… (More)
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Highly Cited
2005
Highly Cited
2005
Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.
BACKGROUND & AIMS Enhanced motility of cancer cells by remodeling of the actin cytoskeleton seems crucial in the process of… (More)
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2005
2005
E-cadherin regulates the association between beta-catenin and actinin-4.
The E-cadherin/catenin system acts as an invasion suppressor of epithelial malignancies. This invasion suppressive activity seems… (More)
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2004
2004
Two distinct classes of CCAAT box elements that bind nuclear factor-Y/alpha-actinin-4: potential role in human CYP1A1 regulation.
A negative regulatory element (NRE1; position -794 to -774) was previously identified that mediates the downregulation of CYP1A1… (More)
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2001
2001
CD2AP and p130Cas localize to different F-actin structures in podocytes.
Mice lacking the 80-kDa CD2-associated protein (CD2AP) develop progressive renal failure that starts soon after birth with… (More)
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2000
2000
Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging.
We have applied fluorescence ratio imaging to the analysis of an actin-binding protein concentration relative to F-actin in… (More)
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