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  • R. Hines
  • Medicine, Biology
  • Journal of biochemical and molecular toxicology
  • 2007 (First Publication: 1 August 2007)
  • Significant changes in drug-metabolizing enzyme (DME) expression occur during ontogeny. Such changes can have a profound effect on therapeutic efficacy in the fetus and child, as well as the risk forExpand
  • D. G. McCarver, R. Byun, R. Hines, M. Hichme, W. Wegenek
  • Biology, Medicine
  • Toxicology and applied pharmacology
  • 1998 (First Publication: 1 September 1998)
  • To pursue the hypothesis that differences in the regulatory region of CYP2E1 are partially responsible for the intersubject variation in in vivo CYP2E1 activity, restriction enzyme digestion andExpand