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ACTN1 protein, human

Known as: actinin, alpha 1 protein, human, Non-Muscle Alpha-Actinin-1, Actinin 1 Smooth Muscle 
Alpha-actinin-1 (892 aa, ~103 kDa) is encoded by the human ACTN1 gene. This protein plays a role in F-actin crosslinking.
National Institutes of Health

Related topics

Related topics

8 relations
ACTN1 geneActin-Binding ProteinCytoskeletal ModelingCytoskeleton

Broader (1)

Actinin

Papers overview

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Highly Cited
2009
Highly Cited
2009
Isoform-Specific Contributions of α-Actinin to Glioma Cell Mechanobiology
Glioblastoma Multiforme (GBM) is a malignant astrocytic tumor associated with low survival rates because of aggressive… 
Highly Cited
2008
Highly Cited
2008
Actin stress fiber pre-extension in human aortic endothelial cells.
Actin stress fibers (SFs) enable cells to sense and respond to mechanical stimuli and affect adhesion, motility and apoptosis. We… 
Highly Cited
2008
Highly Cited
2008
α-Actinin-4 Is Selectively Required for Insulin-induced GLUT4 Translocation*
Insulin induces GLUT4 translocation to the muscle cell surface. Using differential amino acid labeling and mass spectrometry, we… 
Highly Cited
2007
Highly Cited
2007
Intermediate-affinity LFA-1 binds α-actinin-1 to control migration at the leading edge of the T cell
T lymphocytes use LFA‐1 to migrate into lymph nodes and inflammatory sites. To investigate the mechanisms regulating this… 
Highly Cited
2007
Highly Cited
2007
Movement of stress fibers away from focal adhesions identifies focal adhesions as sites of stress fiber assembly in stationary cells.
Force generated in contractile actin filament bundles (stress fibers-SFs) is transmitted to the extracellular matrix (ECM) via… 
Highly Cited
2007
Highly Cited
2007
Alpha-actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction.
Physical forces including pressure, strain, and shear can be converted into intracellular signals that regulate diverse aspects… 
Highly Cited
2006
Highly Cited
2006
Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins.
Highly Cited
2002
Highly Cited
2002
The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner
Cyclin-dependent kinase 5 (Cdk5) is a critical regulator of neuronal migration in the developing CNS, and recent studies have… 
Highly Cited
2002
Highly Cited
2002
Microfilament‐dependent movement of the β3 integrin subunit within focal contacts of endothelial cells
To gain insight into the dynamic properties of focal contacts, we induced expression of green fluorescent protein‐tagged β3… 
Highly Cited
2000
Highly Cited
2000
Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells.
A 38-kd protein that associates with F-actin structures in activated platelets and endothelial cells was purified, cloned, and… 
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