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ABCC3 gene

Known as: MLP2, ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 Gene, MRP3 
This gene is involved in bile metabolism.
National Institutes of Health

Related topics

Related topics

6 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients
Human urinary bladder cancer (UBC) is the one of the most common malignancies worldwide and occurs at a higher frequency in male… 
Highly Cited
2013
Highly Cited
2013
Differences in Transcript Levels of ABC Transporters Between Pancreatic Adenocarcinoma and Nonneoplastic Tissues
Objectives The aim of this study was to evaluate transcript levels of all 49 human ATP-binding cassette transporters (ABCs) in… 
Highly Cited
2013
Highly Cited
2013
MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes
MUC1 (CD227), a membrane tethered mucin glycoprotein, is overexpressed in >60% of human pancreatic cancers (PCs), and is… 
Review
2011
Review
2011
Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCC2 and their impact on drug disposition.
The ATP-binding cassette (ABC) transporter superfamily comprises membrane proteins that translocate a variety of substrates… 
Highly Cited
2010
Highly Cited
2010
Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel.
Review
2007
Review
2007
Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice
The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of… 
Highly Cited
2006
Highly Cited
2006
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.
Highly Cited
2005
Highly Cited
2005
Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene
MRP3 is an ABC transporter localized in the basolateral membrane of epithelial cells such as hepatocytes and enterocytes. In this… 
Highly Cited
2002
Highly Cited
2002
Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.
Phenobarbital (PB) induces the hepatic organic anion transporter, Mrp3. The present study tested the hypothesis that Mrp3… 
Highly Cited
1998
Highly Cited
1998
Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport.
The human multidrug resistance protein (MRP) gene encodes a membrane protein involved in the ATP-dependent transport of… 
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