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A 771726

Known as: a 77-1726, A77 1726, A-771726 
National Institutes of Health

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6 relations

Broader (6)

2-hydroxyethylidene-cyanoacetic acid-4-trifluoromethyl anilideAniline CompoundsAnti-Inflammatory Agents, Non-SteroidalHydroxybutyrates

Papers overview

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2018
2018
A77 1726 (leflunomide) blocks and reverses cardiac hypertrophy and fibrosis in mice.
T-cell infiltration and the subsequent increased intracardial chronic inflammation play crucial roles in the development of… 
2015
2015
Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus
Purposes. To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F… 
Review
2013
Review
2013
Teriflunomide for the Treatment of Relapsing Multiple Sclerosis
Objective: To review the pharmacology and clinical data for teriflunomide in relapsing multiple sclerosis (MS). Data Sources: A… 
2011
2011
Leflunomide Induces Apoptosis in Fludarabine-Resistant and Clinically Refractory CLL Cells
Purpose: Environmental conditions in lymph node proliferation centers protect chronic lymphocytic leukemia (CLL) cells from… 
2009
2009
ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.
2005
2005
An active metabolite of leflunomide, A77 1726, inhibits the production of serum amyloid A protein in human hepatocytes.
OBJECTIVE Cytokine-induced hepatic serum amyloid A (SAA) synthesis is the critical step in the pathogenesis of AA amyloidosis… 
2004
2004
Rapid determination of the active leflunomide metabolite A77 1726 in human plasma by high-performance liquid chromatography.
2004
2004
A 771726, the Active Metabolite of Leflunomide, Inhibits TNF-α and IL-1 from Kupffer Cells
This study was conducted to investigate the importance of direct contact between Kupffer cells (KCs) and hepatocytes (HCs) during… 
2004
2004
A 771726, the active metabolite of leflunomide, inhibits TNF-alpha and IL-1 from Kupffer cells.
This study was conducted to investigate the importance of direct contact between Kupffer cells (KCs) and hepatocytes (HCs) during… 
1998
1998
Malononitrilamides synergistically prevent acute and treat ongoing skin allograft rejection with cyclosporine
Abstract The low molecular weight malononitrilamides (MNAs), a new class of immunosuppressive agents, belong to the derivatives… 
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