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A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models.
- J. Parke, N. Holford, B. Charles
- Medicine, Computer Science
- Computer methods and programs in biomedicine
- 1 April 1999
A method is presented for automated preparation of bootstrap data samples and their presentation to NONMEM for use in the validation of population pharmacokinetic or pharmacodynamic models, which… Expand
Population Pharmacokinetics of Hydroxychloroquine in Patients With Rheumatoid Arthritis
Hydroxychloroquine (HCQ) is an antimalarial drug that is also used as a second-line treatment of rheumatoid arthritis (RA). Clinically, the use of HCQ is characterized by a long delay in the onset of… Expand
Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis.
AIMS To investigate the concentration-effect relationship and pharmacokinetics of leflunomide in patients with rheumatoid arthritis (RA). METHODS Data were collected from 23 RA patients on… Expand
Population Pharmacokinetics of Metformin in Late Pregnancy
The pharmacokinetic disposition of metformin in late pregnancy was studied together with the level of fetal exposure at birth. Blood samples were obtained in the third trimester of pregnancy from… Expand
Caffeine Citrate Treatment for Extremely Premature Infants With Apnea: Population Pharmacokinetics, Absolute Bioavailability, and Implications for Therapeutic Drug Monitoring
- B. Charles, Sarah Townsend, P. Steer, V. Flenady, P. Gray, A. Shearman
- Therapeutic drug monitoring
- 1 December 2008
The objective of this study was to develop a population model of the pharmacokinetics (PK) of caffeine after orogastric or intravenous administration to extremely premature neonates with apnea of… Expand
Saliva as a valid alternative to serum in monitoring intravenous caffeine treatment for apnea of prematurity.
Caffeine is a potentially useful alternative to theophylline for the treatment and prevention of apnea of prematurity because of its lower toxicity and longer terminal half-life. Monitoring of… Expand
Population Pharmacokinetics of Vancomycin in Premature Malaysian Neonates: Identification of Predictors for Dosing Determination
- Y. Lo, J. G. V. van Hasselt, Siow-Chin Heng, Chin-Theam Lim, Toong-Chow Lee, B. Charles
- Antimicrobial Agents and Chemotherapy
- 12 April 2010
ABSTRACT The present study determined the pharmacokinetic profile of vancomycin in premature Malaysian infants. A one-compartment infusion model with first-order elimination was fitted to serum… Expand
Population pharmacokinetics of intravenous caffeine in neonates with apnea of prematurity
- T. C. Lee, B. Charles, P. Steer, V. Flenady, A. Shearman
- Clinical pharmacology and therapeutics
- 1 June 1997
To study the population pharmacokinetics of caffeine after intravenous administration to premature infants with apnea.
Reactions of cisplatin hydrolytes with methionine, cysteine, and plasma ultrafiltrate studied by a combination of HPLC and NMR techniques.
- M. El-khateeb, T. Appleton, L. Gahan, B. Charles, S. Berners-Price, A. M. Bolton
- Chemistry, Medicine
- Journal of inorganic biochemistry
- 1 October 1999
The reactions of cis-[PtCl(NH3)2(H2O)]+ with L-methionine have been studied by 1D 195Pt and 15N NMR, and by 2D[1H, 15N] NMR. When the platinum complex is in excess, the initial product,… Expand
Population Pharmacokinetics of Itraconazole and its Active Metabolite Hydroxy-Itraconazole in Paediatric Cystic Fibrosis and Bone Marrow Transplant Patients
- S. Hennig, C. Wainwright, S. Bell, H. Miller, L. Friberg, B. Charles
- Clinical pharmacokinetics
AbstractObjective: The objective of the study was to characterise the population pharmacokinetic properties of itraconazole and its active metabolite hydroxyitraconazole in a representative… Expand