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A 61603

Known as: A-61603 
National Institutes of Health

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2 relations

Broader (2)

ImidazolesTetrahydronaphthalenes

Papers overview

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2020
2020
INPHARMA based determination of ligand binding modes at α1-adrenergic receptors explains the molecular basis of subtype selectivity.
The structural poses of ligands that bind weakly to protein receptors are challenging to define. In this work we have studied… 
2013
2013
Restorative effects of alpha-1A adrenergic are detectable using T2* and targeted nanoparticles in a mouse myocardial infarction (MI) model
Background Apoptosis is believed to play a major role in the progressive weakening of the peri-infarct and remote zone myocardium… 
2010
2010
Cardiac magnetic resonance detection of dynamic apoptotic signaling in vivo following anti-apoptotic therapy
Background Doxorubicin (DOX) is a widely used chemotherapy drug that causes irreversible cardiomyopathy in a growing number of… 
2007
2007
α1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised rats
It has been recently shown that the supersensitivity of distal segments of the rat tail artery to phenylephrine after chemical… 
2006
2006
Selective agonists reveal alpha(1A)- and alpha(1B)-adrenoceptor subtypes in caudal artery of the young rat.
Multiple alpha(1)-adrenoceptors were evaluated in caudal artery of the young Wistar rat using selective agonists and antagonists… 
2003
2003
The alpha 1-adrenoceptor profile in human skeletal muscle resistance arteries in critical limb ischaemia.
OBJECTIVE We recently reported the hyper-responsiveness of human skeletal muscle resistance arteries (SkMRAs) to noradrenaline in… 
2002
2002
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine…
N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1) is a novel alpha(1) agent having the unique profile of alpha… 
2001
2001
Comparison of alpha 1-adrenoceptor agonists in canine urethral pressure profilometry and abdominal leak point pressure models.
2001
2001
The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries.
In this study, alpha(1)-adrenoceptor subtypes were characterised in rat femoral resistance arteries mounted on a small vessel… 
1999
1999
Analysis of alpha 1L-adrenoceptor pharmacology in rat small mesenteric artery.
1. To illuminate the controversy on alpha 1A- or alpha 1L-adrenoceptor involvement in noradrenaline-mediated contractions of rat… 
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